Results 61 to 70 of about 583,247 (311)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Comparison of Oral Sodium Compounds for the Correction of Acidosis

Journal of Dairy Science, 1997
Three Na compounds were tested to determine which was best able to treat metabolic acidosis in dairy cows. Metabolic acidosis was induced in test cows by feeding a diet that was high in anions for 7 d before the administration of treatment on d 8. The orally administered treatments were equivalent amounts of Na in the form of NaCl (208.6 g), NaHCO3 ...
D R, Bigner, J P, Goff, M A, Faust, H D, Tyler, R L, Horst   +4 more
openaire   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Effect of sodium rich pretreatments and processing conditions on microstructure and property evolution of sodium cobalt oxide thermoelectric materials [PDF]

, 2014
Global environmental and sustainability issues have led to a growth in interest in oxide based thermoelectric materials. Sodium cobalt oxide, which presents low toxicity, is one of the most promising p-type thermoelectric materials for high temperature ...
Jakubczyk, Ewa
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Dissolution of sodium, aluminum and caustic compounds from bauxite residues [PDF]

, 2015
Bauxite residues consist of solid particles and a strongly alkaline liquid. Depending on the selected disposal method, the solids content of washed bauxite residues varies from 30 to 70 w-%.
Kinnarinen, Teemu, Holliday, Lloyd, Häkkinen, Antti   +2 more
core   +1 more source

Synthesis and Characterization of Substituted 4-Methoxy-1H-quinolin-2-ones

E-Journal of Chemistry, 2010
An efficient method for the synthesis of various substituted 4-methoxy-1H-quinolin-2-ones from various substituted aniline with malonic acid, phosphorous oxychloride, sodium methoxide and glacial acetic acid under different conditions is described.
A. K. Ramasamy, V. Balasubramaniam, K. Mohan   +2 more
doaj   +1 more source

Cardiac Glycosides in Human Physiology and Disease: Update for Entomologists

Insects, 2019
Cardiac glycosides, cardenolides and bufadienolides, are elaborated by several plant or animal species to prevent grazing or predation. Entomologists have characterized several insect species that have evolved the ability to sequester these glycosides in
Rif S. El-Mallakh, Kanwarjeet S. Brar, Rajashekar Reddy Yeruva   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source