Results 81 to 90 of about 583,205 (201)

Differential Relaxant Responses of Guinea-pig Lung Strips and Bronchial Rings to Sodium Nitroprusside: A Mechanism Independent of cGMP Formation

, 1995
The biochemical mechanism subserving smooth muscle relaxant effects of sodium nitroprusside was examined on U46619, 9, 11-dideoxy-9α, 11α-methanoepoxy PGF2α, precontracted guinea-pig lung strips and hilar bronchial rings.
W S Fred Wong, Jerome H Fleisch, Carlos R Roman   +2 more
core   +1 more source

Cyclodextrin‐Based Supramolecular Complex Modulates the Bioaccessibility and Vascular Activity of Plinia peruviana Extract

ChemistryOpen, Volume 15, Issue 9, September 2026.
Cyclodextrin complexation improved the delivery of plant polyphenols by increasing intestinal bioaccessibility while preserving vascular activity and maintaining low oral toxicity. This strategy highlights the potential of supramolecular systems to enhance the therapeutic value of natural products for cardiovascular health.
Priscila L. Paula, Nubia B. Andrade, Matheus T. Branca, Lucas de Araújo Carvalho, Bruno A. de Oliveira, Adilson D. da Silva, Angela C. Resende, Lara M. Campos, José Maria Barbosa‐Filho, Luiz Fernando C. Oliveira, Vinícius N. Rocha, Ângelo Márcio L. Denadai, Rodrigo L. Fabri   +12 more
wiley   +1 more source

Efficacy of sodium nitroprusside combined with verapamil in the treatment of no-reflow during coronary interventional therapy

Cardiology Plus, 2019
Context: The possible pathophysiological mechanisms of no-reflow are ischemic injury, reperfusion injury, endothelial injury, distal thromboembolism, etc., Moreover, no-reflow can also remarkably increase the risks of acute myocardial infarction, heart ...
Chao Gao, Lei Wang, Linghua Li, Peijun Shao, Fengtian Li, Chao Kang, Jianjun Dai   +6 more
doaj   +1 more source

Gold Nanoparticles Coated With the Antimicrobial Peptide Os‐C(W5): Anticandidal and Biological Activity

Journal of Peptide Science, Volume 32, Issue 9, September 2026.
Gold nanoparticles conjugated with a tick‐derived antimicrobial peptide, Os‐C(W5), demonstrate enhanced proteolytic stability and potent antifungal activity against Candida albicans biofilms and planktonic cells. These non‐cytotoxic nanoconjugates represent a promising biocompatible strategy for combating resistant fungal infections while maintaining ...
P. J. Palm, R. R. Chirombo, C. K. Chiramba, J. C. Serem, H. Taute, M. van der Walt, A. R. M. Gaspar, M. J. Bester   +7 more
wiley   +1 more source

Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling

Andrology, Volume 14, Issue 6, Page 1831-1846, September 2026.
ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu, Peng Hu, Zizhong Yang, Zhenghui Jin, Xiaoyu Zhu, Tao Wang, Jihong Liu, Kai Cui   +7 more
wiley   +1 more source

Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern, Traver J. Wright, Erik D. Marchant, Sean P. Kilroe, William J. Durham, E. Lichar Dillon, Marc M. Baum, Michael P. Kinsky, William K. Russell, Christopher S. Fry, Pratik Gongloor, Richard B. Pyles, Randall J. Urban, Blake B. Rasmussen, Melinda Sheffield‐Moore   +14 more
wiley   +1 more source

Requirement for bivalent cations in the actions of insulin and sodium nitroprusside on metabolism in rat adipocytes [PDF]

, 1986
The requirement for Ca2+ and Mg2+ in the actions of insulin and sodium nitroprusside on rat adipocyte metabolism was investigated: (i) sodium nitroprusside, but not insulin, increased cGMP levels in cells incubated in the absence of Ca2+ and/or Mg2+; (ii)
Shahin Emami, Michael C. Perry, Emami, Shahin, Perry, Michael C.   +3 more
core   +1 more source

Further InvestigationsRegardingthe Toxicityof Sodium Nitroprusside

, 1986
Sodium nitroprusside is a valuable vasodilator, but its use has been curtailed because of numerous reports that, in the presenceof blood,nitroprussidedecomposeswithreleaseof toxic cyanide.
McGinnis, Joseph, Butler, A. R., Christopher Glideweil, Anthony R. Butler, William I. K. Blsset, Gildewell, C., Bisset, W. I K, Joseph Mcginnis   +7 more
core  

Photolysis of sodium nitroprusside and nitroprussic acid

, 1963
The pH of neutral solutions of sodium nitroprusside decreases on irradiation with ultraviolet light. On cutting off the light, the pH slowly rises and tends to reach its original value. If irradiation is far too prolonged, secondary reactions set in, and
Mitra, R. P., Jain, D. V. S., Chari, K. V. R., Banerjee, A. K.   +3 more
core   +1 more source

Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory

Heart International, 2011
Previous studies evidenced that a portion of normotensive Sprague–Dawley rats spontaneously exhibit lower baroreflex sensitivity, however, it was no yet investigated in Wistar rats.
Celso Ferreira, Oseas F. Moura Filho, Hugo Macedo Junior, Luiz Carlos de Abreu, Vitor E. Valenti   +4 more
doaj   +1 more source