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Pentobarbital Sodium: Variation in Toxicity

Science, 1966
The survival rate of groups of female mice given a standard dose of pentobarbital sodium varied during a 12-hour period. When survival rate was plotted against time, a curve with several inflections was described.
H A, Lindsay, V S, Kullman
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Pentobarbital suppresses human brain sodium channels

Molecular Brain Research, 1989
Ion channels, key components in neuronal signal transmission and processing, are likely to be important molecular sites of anesthetic action. Sodium channels from human brain tissue were incorporated into planar lipid bilayers in the presence of batrachotoxin and exposed to the anesthetic pentobarbital.
C, Frenkel   +3 more
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Injectable sodium pentobarbital: Stability at room temperature

Journal of Pharmacological and Toxicological Methods, 2015
Sodium pentobarbital (Nembutal) is a barbiturate used in research as an anesthetic in many animal models. The injectable form of this drug has lately become difficult to procure and prohibitively expensive. Due to this lack of availability, researchers have begun to compound injectable sodium pentobarbital from so-called "nonpharmaceutical ...
Sydney M, Priest, Timothy P, Geisbuhler
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Pentobarbital Sodium Anesthesia in the Syrian Hamster*

Journal of the American Pharmaceutical Association (Scientific ed.), 1946
The Syrian hamster (Cricetus auratus) was studied to determine an effective dosage of pentobarbital sodium in relation to the length and depth of general anesthesia produced. In general, the hamster has an apparently greater tolerance to pentobarbital sodium both in anesthetic and lethal doses than the rat, guinea pig, or rabbit.
F J, ORLAND, P M, ORLAND
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