Results 31 to 40 of about 40,981 (212)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, EarlyView.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

Sustainable Synaptic Device with Two‐Dimensional Ferroelectric Materials for Neuromorphic Computing

Advanced Science, EarlyView.
α‐In2Se3 based FeSFETs can be utilized as sustainable devices through polarization switching governed by both out‐of‐plane and in‐plane polarizations. Upon reaching a fatigued state, current annealing enabled by conductance modulation can significantly enhance the endurance of FeSFETs.
Jaewook Yoo, Seokjin Oh, Minah Park, Jong Min Song, Hongseung Lee, Seohyeon Park, Sojin Jung, Seongbin Lim, Soohyun Lim, Dongsun Shin, Ji Won Heo, TaeWan Kim, Hagyoul Bae   +12 more
wiley   +1 more source

ROS‐Responsive Nanobubbles for Dual‐Enhanced Ultrasound and Magnetic Resonance Imaging of Tumor Oxidative Stress

Advanced Science, EarlyView.
We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung, Youngju Son, Dong Yun Lee, Youngeun Jeon, Muhammad Asaddudin, Sung‐Hong Park, Sangyong Jon   +6 more
wiley   +1 more source

A Stretchable, Mechanically‐Interlocked Polyrotaxane Hydrogel for Wearable Motion and Electrophysiological Monitoring

Advanced Science, EarlyView.
A mechanically interlocked polyrotaxane hydrogel integrates sliding macrocycles within a covalent network, yielding skin‑like softness, high stretchability, robust adhesion, and stable ionic conductivity. This multifunctional interface enables simultaneous high‑fidelity monitoring of human motion and epidermal electrophysiological signals (ECG/EMG ...
Hao‐Zheng Huang, Yu‐Tao Zheng, Feng Chen, Jing‐Yi Li, Wen‐Hui Zhang, Liang Ding, Zhegang Huang, Wei Jiang, Li‐Ping Huang, Xing‐Can Shen   +9 more
wiley   +1 more source

Adhesion‐Driven Removal of Microplastics From Aquatic Systems by Using Microgel Glues

Advanced Science, EarlyView.
Soft polymeric microgels function as “glues” that aggregate diverse microplastics through multivalent adhesion, promoting their interfacial deposition and co‐precipitation for efficient removal from water. Remarkably, this approach remains effective even for nanoscale plastic particles as small as 50 nm.
Jinmeng Zhang, Jie Xu, Wen Chen, Yanping Chen, Zixin Pan, Weitai Wu   +5 more
wiley   +1 more source

CMOS‐Integrated Synaptic Photoreceptor Chip Inspired by Insect Visual Processing

Advanced Science, EarlyView.
CMOS‐integrated Si QDs/ReS2 synaptic photoreceptor array mimics the parallel processing and wavelength‐selective strategy of insect vision. By combining intrinsic ultraviolet‐violet sensitivity with synaptic plasticity, the chip enables frontend sensory redundancy reduction without external filters, offering a scalable pathway toward lowpower ...
Jian Chai, Xinyi Xu, Yue Wang, Xiaochen Wang, Hailiang Wang, Yunfei Xie, Xinwei Zhang, Haoyu Wang, Hao Ning, Jiangming Lin, Yongliang Xie, Qihai Jiang, Baoshi Qiao, Xiaolei Ding, Luyao Ma, Shukai Duan, Zhenyi Ni, Huan Hu, Xin He, Fei Xue, Feichi Zhou, Lingfei Li, Srikrishna Chanakya Bodepudi, Rui Yuan, Bin Yu, Yang Xu   +25 more
wiley   +1 more source