Results 101 to 110 of about 843,847 (286)

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Identification and comparative analysis of subolesin/akirin ortholog from Ornithodoros turicata ticks

Parasites & Vectors, 2015
Background Subolesin is an evolutionary conserved molecule in diverse arthropod species that play an important role in the regulation of genes involved in immune responses, blood digestion, reproduction and development.
Hameeda Sultana, Unnati Patel, Daniel E Sonenshine, Girish Neelakanta   +3 more
doaj   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Functionalization and Metal Ion Encapsulation Within a Triaxial Supramolecular Weave

Angewandte Chemie, EarlyView.
The functionalization of a triaxially woven supramolecular weave was achieved. Pre‐assembly modification of the peptide‐perylene monoimide building block enabled facile and homogeneous introduction of acetyl, pivaloyl and thiophene moieties throughout the assembly without disrupting the woven structure.
Andreas Herdlitschka, Tatiana Da Silva‐Ferreira, Joseph F. Woods, Man Him Chak, Elisabeth Engelsberger, Bartosz Lewandowski, Helma Wennemers   +6 more
wiley   +2 more sources

Detection of ASFV VP72 gene in soft ticks by real time PCR.

, 2019
ASFV infection was tested in soft ticks for the following viral strain associations: O. moubata-Liv13/33 (OmL), O. moubata-Georgia2007/1 (OmG), O. erraticus-OurT88/1 (OeO), O. erraticus-Georgia2007/1 (OeG) and O. verrucosus-Urk12/Zapo (OvZ).
Laurence Vial (479592), Serhii Filatov (4504453), Maxime Duhayon (8053172), Rémi Pereira de Oliveira (8053169), Adalberto Perez de Leon (8053175), Frédéric Paboeuf (2172187), Evelyne Hutet (2172193), Marie-Frédérique Le Potier (2172190), Fernando Boinas (169953)   +8 more
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Development of microsatellite markers for the soft tick Ornithodoros phacochoerus

Parasites & Vectors
Abstract Background Soft ticks of the genus Ornithodoros are responsible for the maintenance and transmission of the African swine fever (ASF) virus in the sylvatic and domestic viral cycles in Southern Africa. They are also the main vectors of the Borrelia species causing relapsing fevers.
Taraveau, Florian, Bru, David, Quembo, Carlos, Jourdan-Pineau, Hélène   +3 more
openaire   +5 more sources

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

Nanoscale Buried Interface Control in Silicone Hydrogels Enables a Biointerface Engineering Platform

Advanced Science, EarlyView.
A hydrophilic coating with controllable nanoscale thickness is applied to commercial silicone hydrogel contact lenses. By combining comprehensive multi‐modal three‐dimensional characterization with an advanced algorithm, the thickness and chemical information of these multilayered structures are resolved.
Po‐Hsiang Chen, Jia‐Hua Wang, Ching Chen, Shih‐Hsuan Fu, Rajan Deepan Chakravarthy, Hsin‐Chieh Lin   +5 more
wiley   +1 more source

Molecular Detection and Characterization of Tick-Borne Pathogens in Ixodes ricinus Ticks Collected from Humans

Ticks carry numerous pathogens that, if transmitted, can cause disease in humans and animals. Research on pathogens transmitted from ticks to humans is essential for improving public health strategies against tick-borne diseases (TBDs).
Marina Žekić, Cerar Kišek, Tjaša, Vladimir Gajdov, Potkonjak, Aleksandar, Aleksandar Jurišić, Vesna Cvitković-Špik, Gajdov, Vladimir, Savić, Sara, Žekić, Marina, Ružić-Sabljić, Eva, Jurišić, Aleksandar, Sara Savić, Aleksandar Potkonjak, Cvitković-Špik, Vesna, Eva Ružić-Sabljić, Tjaša Cerar Kišek   +15 more
core   +1 more source