Results 91 to 100 of about 843,847 (286)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Sticker Valence Governs Chain Collapse and Liquid‐Liquid Phase Separation in Peptide‐Inspired Associative Polymers

Advanced Science, EarlyView.
Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh, Jinhoon Lee, Seunghyun Lee, Raehyun Jung, Sangyeop Lee, Su‐Mi Hur, Dong Woog Lee, Soo‐Hyung Choi   +7 more
wiley   +1 more source

Identification of African swine fever virus-like elements in the soft tick genome provides insights into the virus’ evolution

BMC Biology, 2020
Background African swine fever virus (ASFV) is a most devastating pathogen affecting swine. In 2007, ASFV was introduced into Eastern Europe where it continuously circulates and recently reached Western Europe and Asia, leading to a socio-economic crisis
Jan H. Forth, Leonie F. Forth, Samantha Lycett, Lesley Bell-Sakyi, Günther M. Keil, Sandra Blome, Sébastien Calvignac-Spencer, Antje Wissgott, Johannes Krause, Dirk Höper, Helge Kampen, Martin Beer   +11 more
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

African swine fever virus – the possible role of flies and other insects in virus transmission

Journal of Veterinary Research, 2020
African swine fever (ASF) is an acute viral haemorrhagic disease of pigs and wild boars. It presents a serious threat to pig production worldwide, and since 2007, ASF outbreaks have been recorded in the Caucasus, Eastern Europe, and the Baltic States. In
Fila Mateusz, Woźniakowski Grzegorz
doaj   +1 more source

Rapid Photogelation of Low‐Concentration Polymer Solutions via Photodimerization of o‐Ethylnitrobenzene

Advanced Science, EarlyView.
Upon UV irradiation, flexible and tough hydrogels are formed rapidly (>0.5 s) from dilute (>0.5 wt%) solutions of o‐ethylnitrobenzene–modified PVA. At ∼1.5 wt%, the hydrogels withstand up to 10 MPa compression, remain handleable even after 200‐fold swelling.
Masaaki Okihara, Ayaka Tomoda, Kana Morishita, Toshiyuki Takagi, Kimio Sumaru   +4 more
wiley   +1 more source

Evolution, expansion and expression of the Kunitz/BPTI gene family associated with long-term blood feeding in Ixodes Scapularis

BMC Evolutionary Biology, 2012
Background Recent studies of the tick saliva transcriptome have revealed the profound role of salivary proteins in blood feeding. Kunitz/BPTI proteins are abundant in the salivary glands of ticks and perform multiple functions in blood feeding, such as ...
Dai Shao-Xing, Zhang Ai-Di, Huang Jing-Fei   +2 more
doaj   +1 more source

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

Advanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang, Hui Wang, Hao Zhang, Zhenkuan Cao, Zehui Liu, Siying Li, Hongda Wang, Yuping Shan   +7 more
wiley   +1 more source

Subolesin/akirin orthologs from Ornithodoros spp soft ticks: cloning, RNAi gene silencing and protective effect of the recombinant proteins

, 2012
29 p., 3 tablas, 4 figurasSubolesin/akirin is a well characterized protective antigen highly conserved across vector species and thus potentially useful for the development of a broad-spectrum vaccine for the control of arthropod infestations including ...
Verónica Díaz-Martín, Raúl Manzano-Román, Siles Lucas, Mar, Manzano Román, Raúl, Oleaga, Ana, Ana Oleaga, Díaz Martín, Verónica, Mar Siles-Lucas, Ricardo Pérez-Sánchez, Pérez Sánchez, Ricardo   +9 more
core   +1 more source

Ticks (Acari: Ixodidae) on birds migrating to the island of Ponza, Italy, and the tick-borne pathogens they carry

, 2021
Seasonal migration of birds between breeding and wintering areas can facilitate the spread of tick species and tick-borne diseases. In this study, 151 birds representing 10 different bird species were captured on Ponza Island, an important migratory ...
Sveriges lantbruksuniversitet., Cardinale, Massimiliano,   +1 more
core   +1 more source