Results 121 to 130 of about 1,401,689 (359)

Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway

Molecular Medicine
Background Soy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the therapeutic potential of SI in the treatment of osteosarcoma (OS) and to investigate the underlying ...
Ziang Zheng, Xinghan Zhao, Bo Yuan, Shan Jiang, Rushan Yan, Xiaowei Dong, Qijun Yao, Haidong Liang   +7 more
doaj   +1 more source

Mitochondria dysfunction and increased expression of WNT5A and BNIP3 in tenocytes obtained from patients with tendinopathy

JSES International
: Background: Tendinopathy is a significant source of pain and functional impairment, with contributions from various extrinsic and intrinsic factors.
Yusuke Nakagawa, MD, PhD, Yuki Okazaki, MD, PhD, Camila B. Carballo, PT, PhD, Susumu Wada, MD, PhD, Daniel Nemirov, MD, Elizabeth R. Selvaggio, MD, Amir H. Lebaschi, MD, Xiang-Hua Deng, MD, Miguel Otero, PhD, Michelle L. Delco, DVM, PhD, Lisa A. Fortier, DVM, PhD, Scott A. Rodeo, MD   +11 more
doaj   +1 more source

Don't cancel the surgery just yet! A case report of positive preoperative pregnancy test due to a soft tissue sarcoma production of ectopic beta human chorionic gonadotropin. [PDF]

, 2018
Soft tissue sarcomas are a rare group of mesenchymal malignancies which can range from low to high grade. These tumors have different clinical, radiographic, and histopathological characteristics. Beta human chorionic gonadotropin is a naturally secreted
Blank, Alan Todd, Jones, Kevin B, Khalighi, Mazdak, Randall, R Lor   +3 more
core  

Systematic assessment of soft tissue level and bone level dental implants

, 2023
Laura Lago, Luís Henrique Mendes da Silva, Noelia Fernández‐Formoso, Benito Rilo   +3 more
openalex   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Patterning the Void: Combining L‐Systems with Archimedean Tessellations as a Perspective for Tissue Engineering Scaffolds

Advanced Functional Materials, EarlyView.
This study introduces a novel multi‐scale scaffold design using L‐fractals arranged in Archimedean tessellations for tissue regeneration. Despite similar porosity, tiles display vastly different tensile responses (1–100 MPa) and deformation modes. In vitro experiments with hMSCs show geometry‐dependent growth and activity. Over 55 000 tile combinations
Maria Kalogeropoulou, Kenny A. van Kampen, Pierpaolo Fucile, Carlos Mota, Lorenzo Moroni   +4 more
wiley   +1 more source

Additively Manufactured Diamond for Energy Scavenging and Wireless Power Transfer in Implantable Devices

Advanced Functional Materials, EarlyView.
Additive manufacturing is expanding beyond mechanical prosthetics into microelectronic implants. This work presents a diamond‐titanium hybrid that enables wireless power transfer, localized heating, and flow sensing. The use of additive manufacturing combined with the biocompatibility of the diamond‐titanium hybrid material paves the way toward new ...
Joshua Zarins, Daniel De Maria, Alan Jones, Deepak Sharma, Amir Ebrahimi, Zhangyu Xu, Omid Kavehei, Peter C. Sherrell, Kate Fox, Arman Ahnood   +9 more
wiley   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Presumed choroidal metastasis from soft tissue myoepithelial carcinoma [PDF]

, 2019
Purpose: To report a case of presumed choroidal metastasis from soft tissue myoepithelial carcinoma and highlight challenges in its diagnosis. Observations: A 52-year-old man was referred with a two-week history of photopsia in his left eye.
Bonar, Fiona, Fung, Adrian T, Hong, Angela M, Hui, Michelle M, Merani, Rohan   +4 more
core   +1 more source

Mechanically Tunable Bone Scaffolds: In Vivo Hardening of 3D‐Printed Calcium Phosphate/Polycaprolactone Inks

Advanced Functional Materials, EarlyView.
A 3D bone scaffold with osteogenic properties and capable of hardening in vivo is developed. The scaffold is implanted in a ductile state, and a phase transformation of the ceramic induces the stiffening and strengthening of the scaffold in vivo. Abstract Calcium phosphate 3D printing has revolutionized customized bone grafting.
Miguel Mateu‐Sanz, Pablo Varela, Laura del‐Mazo‐Barbara, Irene Lodoso‐Torrecilla, Emilio Jiménez‐Piqué, Jordi Franch, Miguel Alaminos, Maria‐Pau Ginebra   +7 more
wiley   +1 more source