Results 91 to 100 of about 713,425 (307)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Empirische Bestandsaufnahme des Software-as-a-Service-Einsatzes in kleinen und mittleren Unternehmen [PDF]

open access: yes, 2011
Cloud-Service-Provider werben gerne damit, dass Software-as-a-Service besonders auch für kleines oder mittleres Unternehmen (KMU) attraktiv sei. Diese könnten durch die Benutzung von Cloud-Services Kosten einsparen und ihre IT-Landschaft flexibler ...
Haselmann, Till   +2 more
core  

Exploring Internal Challenges in Internationalisation: A Case of a Software as a Service (SaaS) Internationaliser

open access: yesEuropean Management Studies
Purpose: The article examines the internal challenges encountered in internationalisation, focusing on Software as a Service (SaaS) companies. It aims to contribute to the literature on SaaS companies’ internationalisation by examining the unique ...
Karl Erik Õim, Tairi Leis
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Feature Performance Metrics for Software as a Service Offering: The Case of HubSpot [PDF]

open access: yes, 2011
This paper provides an industry case study for measuring the performance of software as a service (SaaS) product features in order to prioritize development efforts.
Latner, Avi, Valerdi, Ricardo
core  

Metodología para la selección de sistemas enterprise resource planning desplegados en la nube para pequeñas y medianas empresas: Aproximación alineada con la realidad ecuatoriana

open access: yesMaskana, 2017
En la actualidad los Sistemas de Planeación de Recursos Empresariales (Enterprise Resource Planning; ERP) representan una herramienta esencial para las empresas que buscan la automatización de sus procesos, de ahí que varias compañías empleen mucho ...
Fabián Carrión, Priscila Cedillo
doaj  

Technological development trends: Application service model (ASP) or 'Cloud Computing' [PDF]

open access: yesAnali Ekonomskog fakulteta u Subotici, 2014
The paper discusses modern technological approaches and Internet concepts that are significantly and rapidly changing the view of the global business world.
Trninić Jelica, Đurković Jovica
doaj  

Financial Software as a Service [PDF]

open access: yes, 2014
Software as a service as one of the cloud delivery models that supports fine-grained components. Financial applications demand better performance and accuracy in a cloud than the traditional computing platforms. Therefore, designing financial software as a service (FSaaS) requires an engineering and systematic approach.
Ramachandran, M, Chang, V
openaire  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Enterprise 2.0 – Is The Market Ready? [PDF]

open access: yes
Enterprise 2.0 family technologies have growing popularity, the cloud computing market is growing rapidly and, as a consequence, companies of all sizes start to evaluate the potential fit.
Dragos Marian MANGIUC
core  

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