Results 71 to 80 of about 121,009,205 (294)
Layered ontological modelling for web service-oriented model-driven architecture [PDF]
, 2005 Modelling is recognised as an essential activity in the architectural design of software systems. Model-driven architecture (MDA) is a framework implementing this idea.
Pahl, Claus
core +3 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
The Business Model of "Software-As-A-Service"
IEEE International Conference on Services Computing (SCC 2007), 2007 The emergence of the software-as-a-service (SaaS) business model has attracted great attentions from both researchers and practitioners. SaaS vendors deliver on-demand information processing services to users, and thus offer computing utility rather than the standalone software itself.
openaire +3 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Quality-aware model-driven service engineering [PDF]
, 2008 Service engineering and service-oriented architecture as an integration and platform technology is a recent approach to software systems integration.
Boskovic, Marko +3 more
core +2 more sources
, 2012 This paper proposes a highly automated mechanism to build an undo facility into a new or existing system easily. Our proposal is based on the observation that for a large set of operators it is not necessary to store in-memory object states or executed system commands to undo an action; the storage of input data is instead enough.
Dieste Tubio, Óscar +3 more
openaire +2 more sources
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
SME and NPO readiness for adopting software-as-a-service in developing countries [PDF]
, 2012 Includes abstract.Includes bibliographical references.This research aims to study [Software-as-a-Service] SaaS readiness and adoption in South Africa.
Madisha, Moritlha
core +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source