Results 61 to 70 of about 86,698,415 (262)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Pattern-driven reuse in architecture-centric evolution for service software [PDF]
, 2012 Service-based architectures implement business processes as technical software services to develop enterprise software. As a consequence of frequent business and technical change cycles, the architect requires a reusecentered approach to systematically ...
Pooyan Jamshidi (5276344) +5 more
core
, 2021 Supplemental material, sj-docx-1-idv-10.1177_02666669211056368 for Measuring factors influencing quality of software-as-a-service by Nurul Huda Basiran and Maryati Mohd.
Maryati Mohd. Yusof (11724260) +1 more
core +1 more source
SOFTWARE DEVELOPMENT BUSINESS MOVING TOWARDS A UNIFIED COLLABORATIVE SYSTEM IN IT. SAAS MAY BE THE NEW ORIENTATION. [PDF]
Annals of the University of Oradea: Economic Science, 2010 In this paper we will present an alternative way of programming. Our opinion is that, in the next few years, software development business will suffer serious changes.
Tolea Eniko Elisabeta +1 more
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Model Checking Approach for Verifying COWS Specifications [PDF]
, 2008 We introduce a logical verification framework for checking functional properties of service-oriented applications formally specified using the service specification language COWS.
Tiezzi, F. +11 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
09021 Executive Summary – Software Service Engineering [PDF]
, 2009 Service-Oriented Architecture (SOA) constitutes an important, standards-based and technology-independent distributed computing paradigm and architectural style for discovering, binding, assembling, and publishing loosely-coupled and network-available ...
Leymann, Frank +3 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source