Results 61 to 70 of about 121,009,205 (294)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Staying Young at the Edge: A Software Aging Perspective for Foundation Models as a Service

Computers
Nowadays, the emergence of Foundation Models as a Service enables mobile users to access powerful capabilities such as inference and fine-tuning on demand and without incurring local computational overhead.
Benedetta Picano, Romano Fantacci
doaj   +1 more source

Cluster as a Service: A Resource Sharing Approach for Private Cloud

Tsinghua Science and Technology, 2016
With the rapid development of cloud computing and big data processing, an increasing number of application frameworks are being considered to run in a “cloud way”. This development brings about several challenges to the enterprise private cloud computing
Donggang Cao, Peidong Liu, Wei Cui, Yehong Zhong, Bo An   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

An Intelligent Self-Configuring Recommender System as a Service

IEEE Access
Recommender systems (RS) typically require significant domain expertise and manual configuration, creating a substantial barrier for non-specialist developers.
Felipe Reboucas Ferreira Abreu, Joel Machado Pires, Frederico Araujo Durao   +2 more
doaj   +1 more source

Debesų kompiuterijos programinės įrangos paslaugų greitaveikos tyrimai / Performance analysis of cloud computing software services

Mokslas: Lietuvos Ateitis, 2019
The paper presents the performance analysis of the developed software as a service. In OpenStack cloud infrastructure, the software services for hemodynamic flow modelling and particle technology applications have been developed by using Apache jclouds ...
Oleg Bystrov, Ruslan Pacevič, Arnas Kačeniauskas   +2 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

SOFTWARE DEVELOPMENT BUSINESS MOVING TOWARDS A UNIFIED COLLABORATIVE SYSTEM IN IT. SAAS MAY BE THE NEW ORIENTATION. [PDF]

Annals of the University of Oradea: Economic Science, 2010
In this paper we will present an alternative way of programming. Our opinion is that, in the next few years, software development business will suffer serious changes.
Tolea Eniko Elisabeta, Costin Aurelian-Razvan   +1 more
doaj  

UkrVO Astroinformatics Software and Web-services [PDF]

Proceedings of the International Astronomical Union, 2016
AbstractThe aim of this paper is to introduce the software and astronomical web-services developed in frame of the Ukraine Virtual Observatory (UkrVO) and VIrtual Roentgen and Gamma Observatory (VIRGO) to the broad astronomical community. We report briefly on such web-services as the public databases “Sky Maps” of X-ray observations by XMM-Newton, the ...
Irina B. Vavilova, Yaroslav S. Yatskiv, Ludmila K. Pakuliak, Ivan L. Andronov, Vitaliy M. Andruk, Yu. I. Protsyuk, Vadym E. Savanevych, D. O. Savchenko, Volodymyr S. Savchenko   +8 more
openaire   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source