Results 61 to 70 of about 710,485 (229)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Feature placement algorithms for high-variability applications in cloud environments [PDF]

, 2012
While the use of cloud computing is on the rise, many obstacles to its adoption remain. One of the weaknesses of current cloud offerings is the difficulty of developing highly customizable applications while retaining the increased scalability and lower ...
De Turck, Filip, Dhoedt, Bart, Joosen, Wouter, Moens, Hendrik, Truyen, Eddy, Walraven, Stefan   +5 more
core   +1 more source

Design and evaluation of an architecture for future smart grid service provisioning [PDF]

, 2012
In recent years, there has been a growing interest in cloud technologies. Using current cloud solutions, it is however difficult to create customizable multi-tenant applications, especially if the application must support varying Quality of Service (QoS)
De Turck, Filip, Develder, Chris, Melis, Stijn, Mets, Kevin, Pollet, Thierry, Strobbe, Matthias, Van de Veire, Stijn, Verschueren, Tom   +7 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Empirische Bestandsaufnahme des Software-as-a-Service-Einsatzes in kleinen und mittleren Unternehmen [PDF]

, 2011
Cloud-Service-Provider werben gerne damit, dass Software-as-a-Service besonders auch für kleines oder mittleres Unternehmen (KMU) attraktiv sei. Diese könnten durch die Benutzung von Cloud-Services Kosten einsparen und ihre IT-Landschaft flexibler ...
Haselmann, Till, Röpke, Christian, Vossen, Gottfried   +2 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

A Local Search Algorithm for Clustering in Software as a Service Networks [PDF]

In this paper we present and analyze a model for clustering in networks that offer Software as a Service (SaaS). In this problem, organizations requesting a set of applications have to be assigned to clusters such that the costs of opening clusters and ...
Gaast, J.P. van der, Gabor, A.F., Rietveld, C.A., Zhang, Y.   +3 more
core   +1 more source

Feature Performance Metrics for Software as a Service Offering: The Case of HubSpot [PDF]

, 2011
This paper provides an industry case study for measuring the performance of software as a service (SaaS) product features in order to prioritize development efforts.
Latner, Avi, Valerdi, Ricardo
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Coordination mechanism of SaaS service supply chain: Based on compensation contracts

Journal of Industrial Engineering and Management, 2013
Purpose: The purpose of this paper is to build new contracts theories of SaaS service supply chain. Software as a Service (SaaS) has become a hot topic in this industry .
Yanli Guo, Jianbin Chen, Hailing Guo, Xinman Lu   +3 more
doaj   +1 more source