Results 81 to 90 of about 2,114,299 (265)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Software Defined User Centric 5G Wireless Network Framework
Dianxin kexue, 2015 The radio access network of 5G is a complex heterogeneous network.The independence of different protocols limits the network performance. To unify the management of the heterogeneous network and provide personalized service，a software defined user ...
Hua Qu +4 more
doaj +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2018 OpenStreetMap offers a valuable source of worldwide geospatial data useful to urban researchers. This study uses the OSMnx software to automatically download and analyze 27,000 US street networks from OpenStreetMap at metropolitan, municipal, and ...
Boeing, Geoff
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Network security through software defined networking
Proceedings of the Conference on Principles, Systems and Applications of IP Telecommunications, 2014 Network security is a predominant topic both in academia and industry. Many methods and tools have been proposed but the attackers are still able to launch massive and effective attacks. Keeping the pace with the new threats appearing or becoming more sophisticated everyday is of a paramount of importance. Software Defined Networking (SDN) has recently
François, Jérôme +3 more
openaire +2 more sources
Resource management for software defined data centers for heterogeneous infrastructures [PDF]
, 2015 Software Defined Data Center (SDDC) provides more resource management flexibility since everything is defined as a software, including the network as Software Defined Network (SDN).Typically, cloud providers overlook the network, which is configured ...
Carneiro do Amaral, Marcelo +1 more
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Software defined airborne tactical network for aeronautic swarm
Tongxin xuebao, 2017 Aeronautic swarm was a new kind of aeronautic operationa1 system inspired by bio1ogica1 swarm behaviors.Whi1e 1eading to a new usage way of future aeronautic operationa1 resources，aeronautic swarm wou1d bring new cha11enges to the airborne tactica1 ...
Shang-hong ZHAO +4 more
doaj +2 more sources
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source