Results 161 to 170 of about 4,685,278 (250)

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Dynamic hyperinflammatory response assessment using HIC scores in COVID-19: application to a large series of patients receiving anakinra. [PDF]

Front Immunol
Amikishiyev S, Deniz R, Gunver MG, Aghamuradov S, Koca N, Ince B, Bektas M, Yilmaz A, Canturk Y, Durak G, Kose M, Erelel M, Çağatay AA, Yavuz SS, Kalayoglu Besisik S, Esen F, Gül A.   +16 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Trial protocol: RadTARGET, a multicenter phase II randomized controlled trial evaluating focal radiotherapy boost with de-intensification of dose to non-suspicious prostate in patients with intermediate- or high-risk prostate cancer. [PDF]

Clin Transl Radiat Oncol
Dornisch AM, Domingo MR, Alexander RV, Conlin CC, Do S, McKay RR, Moiseenko V, Liss MA, Liu J, Pawlicki T, Pena S, Qiao EM, Rose BS, Rupareliya R, Sandhu AP, Scholey J, Seyedin SN, Urbanic JJ, Wei LJ, Seibert TM.   +19 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

"When the Doctor Said Cancer, Everything Stopped": A Qualitative Study of the Lived Experiences of Men With Prostate Cancer in Kenya. [PDF]

J Patient Exp
Njuguna DW, Muthiru AW, Riogi B, Abdihamid O, Waihenya C, Chege S, Kibaya R, Mweni S, Kinya I, Nyabuto L, Murithi J, Kuno I, Caballero A, Afzal U, Makokha F, Cobran E.   +15 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Validation of Automated Software for Guttae Quantification in Fuchs Endothelial Corneal Dystrophy. [PDF]

Transl Vis Sci Technol
Sarin SR, Abou Assi J, Skeie JM, Deman P, Zimmerman MB, McGranahan DM, Troyer JM, Schmidt GA, Potevin F, Greiner MA.   +9 more
europepmc   +1 more source