Results 181 to 190 of about 4,685,278 (250)

OpenPMX Software for Nonlinear Mixed-Effect Models in Pharmacometrics: Precision Compared With NONMEM First-Order Conditional Estimation. [PDF]

CPT Pharmacometrics Syst Pharmacol
Eleveld DJ, Koomen JV, Stevens J, Colin PJ, Struys MMRF.   +4 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Trimmomatic: a decade of feature-rich, high-performance NGS read preprocessing. [PDF]

Bioinformatics
Beier S, Bolger AM, Bolger ME, Schwacke R, Usadel B.   +4 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Development of a Human Electrophysiology Laboratory to Advance Cognitive Neuroscience in Western Kenya. [PDF]

Clin EEG Neurosci
Nafiseh A, Morales J, Nyalumbe M, Oyungu E, Ayuku D, Bolbecker AR, Hetrick WP, McHenry MS.   +7 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Advancing abdominal surgery recovery implementation: a unified framework for intensified recovery protocols by the EUropean PErioperative MEdical Networking collaborative. [PDF]

Front Surg
Ioannidis O, Bourtzinakou AA, Ramirez JM, Fabbri N, Ubieto JM, Feo CV, Pesce A, Rosetzka K, Arroyo A, Kocián P, Sánchez-Guillén L, Bellosta AP, Whitley A, Enguita AB, Teresa-Fernandéz M, Bitsianis S, Symeonidis S, Anestiadou E.   +17 more
europepmc   +1 more source

Comparing the intra- and inter-rater reliability of two outcomes, two software platforms, and three levels of surgical experience for radiographic measurements of surgically treated osteoporotic vertebral compression fractures. [PDF]

Brain Spine
Tsoupras A, Tabard-Fougère A, Al Taha K, Feltri P, Boudabbous S, Dominguez DE, Lauper N.   +6 more
europepmc   +1 more source