Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Towards an effective refactoring taxonomy for sustainable software systems. [PDF]
PLoS OneAlmogahed A +8 more
europepmc +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Bridging the analog divide: a comparison of printed X-ray films and digital images when using computer-aided detection software for tuberculosis screening. [PDF]
BMC Glob Public HealthCodlin AJ +11 more
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Evaluation of the marginal and internal gaps in 3D-printed interim crowns using different finish line detection methods: An in vitro study. [PDF]
PLoS OneHuong NTT +7 more
europepmc +1 more source
Cultures and Organizations: Software of the Mind
, 1991 G. Hofstede, G. Hofstede, Michael Minkov
semanticscholar +1 more source
MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment
Briefings Bioinform., 2004 Sudhir Kumar, K. Tamura, M. Nei
semanticscholar +1 more source