Results 31 to 40 of about 644,389 (264)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Epidemiological Agent-Based Modelling Software (Epiabm)

Journal of Open Research Software
Epiabm is an open-source software package for epidemiological agent-based modelling, re-implementing the well-known CovidSim model from the MRC Centre for Global Infectious Disease Analysis at Imperial College London. It has been developed as part of the
Kit Gallagher, Ioana Bouros, Nicholas Fan, Elizabeth Hayman, Luke Heirene, Patricia Lamirande, Annabelle Lemenuel-Diot, Ben Lambert, David Gavaghan, Richard Creswell   +9 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Discovering Hidden Mental States in Open Multi-Agent Systems by Leveraging Multi-Protocol Regularities with Machine Learning

Sensors, 2020
The agent paradigm and multi-agent systems are a perfect match for the design of smart cities because of some of their essential features such as decentralization, openness, and heterogeneity.
Emilio Serrano, Javier Bajo
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

An overview of agent-based traffic simulators

Transportation Research Interdisciplinary Perspectives, 2021
Individual traffic significantly contributes to climate change and environmental degradation. Therefore, innovation in sustainable mobility is gaining importance as it helps to reduce environmental pollution. However, effects of new ideas in mobility are
Johannes Nguyen, Simon T. Powers, Neil Urquhart, Thomas Farrenkopf, Michael Guckert   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

ABS-FishCount: An Agent-Based Simulator of Underwater Sensors for Measuring the Amount of Fish

Sensors, 2017
Underwater sensors provide one of the possibilities to explore oceans, seas, rivers, fish farms and dams, which all together cover most of our planet’s area.
Iván García-Magariño, Raquel Lacuesta, Jaime Lloret   +2 more
doaj   +1 more source

Lightweight agent-based game AI architecture

Adaptivni Sistemi Avtomatičnogo Upravlinnâ, 2023
The object of research is a game AI and architectural solutions for its development. Game AI is one of the most complicated parts of game development, and it needs good tools to reduce complexity and speed up the development.
K. Hazin, I. Stetsenko
doaj   +1 more source