Results 111 to 120 of about 2,657,708 (305)

Free and open source cloud technology based on the type Software as a Service

open access: yesCTE Workshop Proceedings, 2017
The aim of this study is to design and implement the cloud computing technology with types of the services Software as a Service (SaaS). Objectives of the study is to analyze the free and open source cloud technology based on the type Software as a ...
Nataliya Mihailivna Kiyanovska
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Librarians On Call: an instant messaging enquiry service for Open University distance learners [PDF]

open access: yes, 2003
From March 4 – May 31 2002, The Open University Library piloted a new, instant messaging enquiry service for use by its distance learners, called Librarians On Call.
Payne, Georgina, Perrott, Michelle
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Video Reference: A Pre-Test and Pilot Project [PDF]

open access: yes, 2010
Hennepin County Library will open two new, larger libraries without the ability to increase FTE. We are developing a pilot plan to see if a video service can address the need to provide reference service in a busy library as part of an overall staffing ...
Clifford, Christine, Nelson, Jennifer
core   +1 more source

Simplifying the Development, Use and Sustainability of HPC Software

open access: yes, 2013
Developing software to undertake complex, compute-intensive scientific processes requires a challenging combination of both specialist domain knowledge and software development skills to convert this knowledge into efficient code.
Cantwell, Chris   +7 more
core   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

ADOPTION OF SOFTWARE AS A SERVICE (SAAS) IN SMALL AND MEDIUM-SIZED HOTELS IN TIRANA

open access: yesEnlightening Tourism: A Pathmaking Journal, 2019
Technology moves with a rapid pace and it has touched every aspect of the hospitality industry. Nowadays, this huge industry is facing significant technological changes especially in the hotel sector. With the continuing growth of modern technologies in
Alba Demneri Kruja   +3 more
doaj   +1 more source

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