Results 91 to 100 of about 775,012 (306)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Quality-aware model-driven service engineering [PDF]
, 2008 Service engineering and service-oriented architecture as an integration and platform technology is a recent approach to software systems integration.
Boskovic, Marko +3 more
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Coordination mechanism of SaaS service supply chain: Based on compensation contracts
Journal of Industrial Engineering and Management, 2013 Purpose: The purpose of this paper is to build new contracts theories of SaaS service supply chain. Software as a Service (SaaS) has become a hot topic in this industry .
Yanli Guo +3 more
doaj +1 more source
Declarative rule-based integration and mediation for XML data in web service-based software architectures [PDF]
, 2007 The Application Service Provider (ASP) has started to use Web services to expose data sources and adopted Service Oriented Architecture (SOA) to build data integration infrastructure. XML data integration and mediation in SOA is a complex task.
Zhu, Yaoling
core
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
DataV: Data Visualization on large high-resolution displays
Visual Informatics, 2020 In recent years, the technology and applications of visualizations on large high-resolution displays (LHDs) have received widespread attention because of its perceptual benefits and improved productivity. However, existing work on LHD visualization lacks
Honghui Mei +4 more
doaj +1 more source
Carbon-Aware Software Services
The significant carbon footprint of the ICT sector calls for methodologies to contain carbon emissions of running software. This article proposes a novel framework for implementing, configuring and assessing carbon-aware interactive software services.
Stefano Forti +2 more
openaire +2 more sources
A Template-driven approach for maintainable service-oriented information systems integration [PDF]
, 2009 Service-oriented architecture (SOA) is currently the predominant software integration framework. Web services provide the predominant platform for SOA. SOA as an integration architecture solution supports a range of application scenarios.
Gacitua, Veronica +6 more
core +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source