Results 81 to 90 of about 775,012 (306)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Mokslas: Lietuvos Ateitis, 2019 The paper presents the performance analysis of the developed software as a service. In OpenStack cloud infrastructure, the software services for hemodynamic flow modelling and particle technology applications have been developed by using Apache jclouds ...
Oleg Bystrov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
SOFTWARE DEVELOPMENT BUSINESS MOVING TOWARDS A UNIFIED COLLABORATIVE SYSTEM IN IT. SAAS MAY BE THE NEW ORIENTATION. [PDF]
Annals of the University of Oradea: Economic Science, 2010 In this paper we will present an alternative way of programming. Our opinion is that, in the next few years, software development business will suffer serious changes.
Tolea Eniko Elisabeta +1 more
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Distribution pattern-driven development of service architectures [PDF]
, 2009 Distributed systems are being constructed by composing a number of discrete components. This practice is particularly prevalent within the Web service domain in the form of service process orchestration and choreography.
Barrett,Ronan +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Service architecture design for E-Businesses: A pattern-based approach [PDF]
, 2008 E-business involves the implementation of business processes over the Web. At a technical level, this imposes an application integration problem. In a wider sense, the integration of software and business levels across organisations becomes a significant
Pahl, Claus, Gacitua-Decar, Veronica
core
An ontology for software component matching [PDF]
, 2003 The Web is likely to be a central platform for software development in the future. We investigate how Semantic Web technologies, in particular ontologies, can be utilised to support software component development in a Web environment.
Claus Pahl, Pahl, Claus
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source