Results 61 to 70 of about 1,521,635 (308)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Multi-Value Models for Allocation of Software Component Development Costs Based on Trustworthiness

open access: yesIEEE Access, 2020
The trustworthiness of software is an important attribute. The cost of software development increases with its improvement by software trustworthiness.
Mengyue Wang   +4 more
doaj   +1 more source

A model for developing dependable systems using a component‐based software development approach (MDDS‐CBSD)

open access: yesIET Software, 2023
Component‐based software development (CBSD) is an emerging technology that integrates existing software components to swiftly develop and deploy big and complex software systems with little engineering effort, money, and time.
Hasan Kahtan   +3 more
doaj   +1 more source

Software Component Certification: A Component Quality Model

open access: yesAnais do V Simpósio Brasileiro de Qualidade de Software (SBQS 2006), 2006
Component-based software development is becoming more generalized, representing a considerable market for the software industry. However, several technical issues remain unsolved before the software components industry reaches the maturity as other software industries.
Alexandre Alvaro   +1 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Issues in Component-Based Development: Towards Specification with ADLs [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2006
Software development has been coupled with time and cost problems through history. This has motivated the search for flexible, trustworthy and time and cost-efficient development. In order to achieve this, software reuse appears fundamental and component-
Rafael González, Miguel Torres
doaj  

Protocol Based Interaction in Component-Based Software Systems. [PDF]

open access: yes, 2007
In Component-based development, assembling components into systems is the major activity. Therefore, Components must be integrated through well-defined infrastructure.
Alhazbi, Saleh, Jantan, Aman
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Dependencies Management in Dynamically Updateable Component-Based System. [PDF]

open access: yes, 2007
Component-based software systems achieve their functionalities through interaction between their components. Analyzing the dependencies between systems components is an essential task in system reconfiguration.
Alhazbi, Saleh, Jantan, Aman
core  

A component-based model and language for wireless sensor network applications

open access: yes, 2011
Wireless sensor networks are often used by experts in many different fields to gather data pertinent to their work. Although their expertise may not include software engineering, these users are expected to produce low-level software for a concurrent ...
Balasubramaniam, Dharini   +3 more
core   +1 more source

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