Results 121 to 130 of about 1,676,132 (304)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A programming language for software components
, 2010 Component software has many benefits, most notably increased software re-use; however, the component software process places heavy burdens on programming language technology, which modern object-oriented programming languages do not address.
Kent, Simon David
core
Software Components, Architectures and Reuse. [PDF]
J. Univers. Comput. Sci., 2011 Software Components, Architectures and ...
Pires,Paulo +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Interface protocol inference to aid understanding legacy software components
, 2018 More and more high tech companies are struggling with the maintenance of legacy software. Legacy software is vital to many organizations, so even if its behavior is not completely understood it cannot be thrown away.
Hebig, Regina +5 more
core
Research on efficiency of automation system with robot on linear motion track
Taikomieji Moksliniai TyrimaiThe work presents an assessment of the efficiency and operational costs of modernized manufacturing process. The process consists of turning operations on two CNC lathe machines.
Ernestas Rimša +2 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Software Systems for Robotics An Applied Research Perspective
International Journal of Advanced Robotic Systems, 2008 Over the past 20 years, Defence Research and Development Canada has developed numerous teleoperated unmanned ground vehicles (UGV), many founded on the ANC?US command and control system.
Jack Collier +3 more
doaj