Results 131 to 140 of about 1,676,132 (304)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

An investigation into evolving support for component reuse [PDF]

, 1999
It is common in engineering disciplines for new product development to be based on a concept of reuse, i.e. based on a foundation of knowledge and pre-existing components familiar to the discipline's community.
Lavery, Janet
core  

Technique for Early Reliability Prediction of Software Components Using Behaviour Models. [PDF]

PLoS One, 2016
Ali A, N A Jawawi D, Adham Isa M, Imran Babar M.   +3 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

International systems and software engineering standards for very small entities [PDF]

, 2013
Very Small Entities (VSEs) developing systems or software are very important to the military since the components they develop are often integrated into products made by larger organizations. Failure to deliver a quality product on time and within budget
Gauthier Fanmuy, Gauthier Fanmuy (12620878), O'Connor, Rory, Fanmuy, Gauthier, Claude Y. Laporte, Laporte, Claude, Laporte, Claude Y., Claude Y. Laporte (12588841), O\u27Connor, Rory V., O\u27Connor, Rory, Rory V. O’Connor, Rory V. O'Connor (12588769)   +11 more
core  

Distributed component technologies and their software engineering implications

, 2002
In this state of the art report, we review advances in distributed component technologies, such as the Enterprise Java Beans specification and the CORBA Component Model. We assess the state of industrial practice in the use of distributed components.
Wolfgang Emmerich, Emmerich, W
core   +1 more source

Correction: Technique for Early Reliability Prediction of Software Components Using Behaviour Models. [PDF]

PLoS One, 2016
Ali A, N A Jawawi D, Adham Isa M, Imran Babar M.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Towards a Dynamic Resource Contractualisation for

, 2004
In this paper we present a framework defining the architecture of systems providing software components with means to contractualise their resource access conditions with their deployment environment dynamically.
Software Components Nicolas, Nicolas Le Sommer   +1 more
core  

Protocol Based Interaction in Component-Based Software Systems. [PDF]

, 2007
In Component-based development, assembling components into systems is the major activity. Therefore, Components must be integrated through well-defined infrastructure.
Alhazbi, Saleh, Jantan, Aman
core