Results 41 to 50 of about 2,092,569 (323)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Expression and Analysis of Uncertainty in Deep Foundation Pit Design Scheme Decision-Making

open access: yesAdvances in Civil Engineering
The burgeoning urbanization of major cities has precipitated a critical examination of deep foundation pit projects, with escalating costs, protracted construction phases, complex site conditions, and specialized technical requirements.
Yu Cui   +4 more
doaj   +1 more source

YOLOv7-Branch: A Jujube Leaf Branch Detection Model for Agricultural Robot

open access: yesSensors
The intelligent harvesting technology for jujube leaf branches presents a novel avenue for enhancing both the quantity and quality of jujube leaf tea, whereas the precise detection technology for jujube leaf branches emerges as a pivotal factor ...
Ruijun Jing   +4 more
doaj   +1 more source

Efficient and Robust Syslog Parsing for Network Devices in Datacenter Networks

open access: yesIEEE Access, 2020
Syslog parsing is of vital importance for the detection, diagnosis and prediction of network device failures in a datacenter. A common approach to syslog parsing is to extract templates from historical syslogs, after which syslogs are matched to these ...
Shenglin Zhang   +10 more
doaj   +1 more source

Zero and low carbon buildings: A driver for change in working practices and the use of computer modelling and visualization [PDF]

open access: yes, 2010
Buildings account for significant carbon dioxide emissions, both in construction and operation. Governments around the world are setting targets and legislating to reduce the carbon emissions related to the built environment.
Hetherington, Robina   +2 more
core   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

Gene Ontology-based function prediction of long non-coding RNAs using bi-random walk

open access: yesBMC Medical Genomics, 2018
Background With the development of sequencing technology, more and more long non-coding RNAs (lncRNAs) have been identified. Some lncRNAs have been confirmed that they play an important role in the process of development through the dosage compensation ...
Jingpu Zhang, shuai Zou, Lei Deng
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

MetricHunter: A software metric dataset generator utilizing SourceMonitor upon public GitHub repositories

open access: yesSoftwareX, 2023
Version control systems are pervasively consulted nowadays to obtain software metric datasets. Accordingly, machine learning is applied to predict different aspects of a software including quality monitoring, influence analysis, etc.
Yusuf Özçevik, Osman Altay
doaj   +1 more source

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