Results 51 to 60 of about 2,092,569 (323)
The Synonym management process in SAREL [PDF]
, 2002 The specification phase is one of the most important and least supported parts of the software development process. The SAREL system has been conceived as a knowledge-based tool to improve the specification phase.
Castell Ariño, Núria +1 more
core +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
The social construction of educational technology through the use of proprietary software [PDF]
, 2010 Major strands of science and technology studies (STS) in recent decades have been the 'social shaping of technology' (SST) and 'social construction of technology' (SCOT) movements, whose adherents maintain that technological systems are determined just ...
Bissell, Christopher
core
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Measurement: SensorsThis study aims to explore the application of gallium nitride (GaN) barrier in hardware optimization of micro nano scale electromechanical systems (MEMS), particularly its ability to overcome the limitations of traditional hardware in high-temperature ...
Ji Gu
doaj +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Robotic assembly of modular concrete shells using falsework
Developments in the Built EnvironmentThe rapid development of robotics has the potential to transform the construction industry of the future. One possible application of robots is the assembly of modular concrete shells.
Egor Ivaniuk +9 more
doaj +1 more source
TANGO: Transparent heterogeneous hardware Architecture deployment for eNergy Gain in Operation [PDF]
, 2016 The paper is concerned with the issue of how software systems actually use Heterogeneous Parallel Architectures (HPAs), with the goal of optimizing power consumption on these resources.
Armstrong, Django +9 more
core +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
PyNomo software dataset for sciences and engineering nomogram construction
Data in Brief, 2022 This article examines different python-based codes to be run under PyNomo nomographer software to represent alignment charts or nomograms for formulas commonly used in sciences and engineering studies.
Pedro Martínez-Pagán, Leif Roschier
doaj +1 more source