Results 51 to 60 of about 155,165 (287)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
An Empirical Study on the Effectiveness of Feature Selection for Cross-Project Defect Prediction
IEEE Access, 2019 Software defect prediction has attracted much attention of researchers in software engineering. At present, feature selection approaches have been introduced into software defect prediction, which can improve the performance of traditional defect ...
Qiao Yu +4 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Applied Sciences, 2023 Software defect prediction is an active research area. Researchers have proposed many approaches to overcome the imbalanced defect problem and build highly effective machine learning models that are not biased towards the majority class.
Amani Alqarni, Hamoud Aljamaan
doaj +1 more source
A Systematic Literature Review of Software Defect Prediction: Research Trends, Datasets, Methods and Frameworks [PDF]
, 2015 Recent studies of software defect prediction typically produce datasets, methods and frameworks which allow software engineers to focus on development activities in terms of defect-prone code, thereby improving software quality and making better use of ...
Wahono, R. S. (Romi)
core
, 2018 We report and fix an important systematic error in prior studies that ranked classifiers for software analytics. Those studies did not (a) assess classifiers on multiple criteria and they did not (b) study how variations in the data affect the results ...
Bennin Kwabena Ebo +7 more
core +1 more source
The scientific basis for prediction research [PDF]
, 2012 Copyright @ 2012 ACMIn recent years there has been a huge growth in using statistical and machine learning methods to find useful prediction systems for software engineers.
Shepperd, M
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Extending Developer Experience Metrics for Better Effort-Aware Just-In-Time Defect Prediction
IEEE Access, 2022 Developers use defect prediction models to efficiently allocate limited resources for quality assurance and appropriately make a plan for software quality improvement activities.
Yeongjun Cho +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source