Results 71 to 80 of about 155,165 (287)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

A just-in-time software defect prediction method based on data augmentation

Nantong Daxue xuebao. Ziran kexue ban
Just-in-time (JIT) software defect prediction aims to predict whether code commits during project development and maintenance will introduce defects.In the field of JIT software defect prediction research,model training relies on high-quality datasets ...
YANG Fan; XIA Hongling
doaj   +1 more source

Evaluating defect prediction approaches: a benchmark and an extensive comparison [PDF]

, 2018
Reliably predicting software defects is one of the holy grails of software engineering. Researchers have devised and implemented a plethora of defect/bug prediction approaches varying in terms of accuracy, complexity and the input data they require ...
D'Ambros, Marco, Lanza, Michele, Robbes, Romain   +2 more
core  

On Predicting Rediscoveries of Software Defects [PDF]

, 2021
The same defect may be rediscovered by multiple clients, causing unplanned outages and leading to reduced customer satisfaction. One solution is forcing clients to install a fix for every defect. However, this approach is economically infeasible, because it requires extra resources and increases downtime.
openaire   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Multiview Transfer Learning for Software Defect Prediction

IEEE Access, 2019
Most software defect prediction models usually assume that enough historical training instances with labels are available. Additionally, the training data and the predicted instances should share the same features to ensure the prediction accuracy ...
Jinyin Chen, Yitao Yang, Keke Hu, Qi Xuan, Yi Liu, Chao Yang   +5 more
doaj   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Learning Effective Changes for Software Projects

, 2017
The primary motivation of much of software analytics is decision making. How to make these decisions? Should one make decisions based on lessons that arise from within a particular project?
Krishna, Rahul
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source