Results 71 to 80 of about 198,133 (331)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Machine Learning Approaches for Software Defect Prediction

Applied Computational Intelligence and Soft Computing
This paper analyses existing research about machine learning approaches in software defect prediction as a key element for improving software reliability and quality.
Hijab Zehra Zaidi, Ubaid Ullah, Muddassira Arshad, Hanan Aljuaid, Muhammad Arslan Rauf, Nadeem Sarwar, Rimsha Sajid   +6 more
doaj   +1 more source

Validating Unsupervised Machine Learning Techniques for Software Defect Prediction With Generic Metamorphic Testing

IEEE Access
In the realm of software defect prediction, unsupervised models often step in when labelled datasets are scarce, despite facing the challenge of validating models without prior knowledge of data.
Pak Yuen Patrick Chan, Jacky Keung
doaj   +1 more source

Holistic Parameter Optimization for Software Defect Prediction

IEEE Access, 2022
A software defect prediction (SDP) model identifies the defect-prone modules. Setting appropriate parameters in an SDP model is critical because it affects the model performance.
Jaewook Lee, Jiwon Choi, Duksan Ryu, Suntae Kim   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A Procedure to Continuously Evaluate Predictive Performance of Just-In-Time Software Defect Prediction Models During Software Development

IEEE Transactions on Software Engineering, 2023
Just-In-Time Software Defect Prediction (JIT-SDP) uses machine learning to predict whether software changes are defect-inducing or clean. When adopting JIT-SDP, changes in the underlying defect generating process may significantly affect the predictive ...
Liyan Song, Leandro L. Minku
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

An Empirical Study on the Effectiveness of Feature Selection for Cross-Project Defect Prediction

IEEE Access, 2019
Software defect prediction has attracted much attention of researchers in software engineering. At present, feature selection approaches have been introduced into software defect prediction, which can improve the performance of traditional defect ...
Qiao Yu, Junyan Qian, Shujuan Jiang, Zhenhua Wu, Gongjie Zhang   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Leveraging Ensemble Learning with Generative Adversarial Networks for Imbalanced Software Defects Prediction

Applied Sciences, 2023
Software defect prediction is an active research area. Researchers have proposed many approaches to overcome the imbalanced defect problem and build highly effective machine learning models that are not biased towards the majority class.
Amani Alqarni, Hamoud Aljamaan
doaj   +1 more source