Results 51 to 60 of about 2,127,647 (262)

Wireless Mesh Software Defined Networks (wmSDN) [PDF]

2013 IEEE 9th International Conference on Wireless and Mobile Computing, Networking and Communications (WiMob), 2013
In this paper we propose to integrate Software Defined Networking (SDN) principles in Wireless Mesh Networks (WMN) formed by OpenFlow switches. The use of a centralized network controller and the ability to setup arbitrary paths for data flows make SDN a handy tool to deploy fine-grained traffic engineering algorithms in WMNs.
DETTI, ANDREA, Pisa, C, SALSANO, STEFANO DOMENICO, BLEFARI MELAZZI, NICOLA   +3 more
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A characterisation of reliability tools for Software Defined Networks [PDF]

, 2017
Software Defined Network (SDN) is a new paradigm in networking that introduces great flexibility, allowing the dynamic configuration of parts of the network through centralised programming.
Gallardo, María del Mar, Lavado, Leticia, Merino-Gomez, Pedro, Panizo, Laura   +3 more
core  

Transiently Consistent SDN Updates: Being Greedy is Hard

, 2016
The software-defined networking paradigm introduces interesting opportunities to operate networks in a more flexible, optimized, yet formally verifiable manner. Despite the logically centralized control, however, a Software-Defined Network (SDN) is still
Amiri, Saeed Akhoondian, Ludwig, Arne, Marcinkowski, Jan, Schmid, Stefan   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

MHSDN: A Hierarchical Software Defined Network Reliability Framework design

IET Information Security, 2023
At present, attacks based on the vulnerability of the controller and flooding attacks still constitute a principal threat for hierarchical Software Defined Network (SDN), such as flow table tampering, malicious Application attacks, Distributed Denial of ...
Zhengbin Zhu, Qinrang Liu, Dongpei Liu, ChenYang Ge, Chong Wang   +4 more
doaj   +1 more source

Field-Trial of Machine Learning-Assisted Quantum Key Distribution (QKD) Networking with SDN

, 2018
We demonstrated, for the first time, a machine-learning method to assist the coexistence between quantum and classical communication channels. Software-defined networking was used to successfully enable the key generation and transmission over a city and
Bi, Y., Hugues-Salas, E., Kanellos, G., Nejabati, R., Ntavou, F., Ou, Y., Simeonidou, D., Wang, R., Yan, SY.   +8 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source