Results 71 to 80 of about 2,127,647 (262)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2018 OpenStreetMap offers a valuable source of worldwide geospatial data useful to urban researchers. This study uses the OSMnx software to automatically download and analyze 27,000 US street networks from OpenStreetMap at metropolitan, municipal, and ...
Boeing, Geoff
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Research on Software Defined Network Application in Optical Transmission Network
Dianxin kexue, 2013 In order to study the feasibility of software defined network（SDN）application in optical transmission network, the concept and background of SDN were presented, the drivers and issues of the application of SDN in optical transport networks were analyzed,
Yunbo Li, Han Li, Sheng Liu
doaj +2 more sources
Com o surgimento de novas tecnologias, o crescimento dos serviços de cloud e o exuberante uso de dispositivos móveis, o aumento substantivo de tráfego na rede torna-se inegável. É cada vez mais difícil garantir a qualidade de serviço, Quality of Service (QoS), e uma boa experiência de utilização, Quality of Experience (QoE), de uma rede.
Marek Amanowicz +2 more
openaire +2 more sources
TARN: A SDN-based Traffic Analysis Resistant Network Architecture
, 2017 Destination IP prefix-based routing protocols are core to Internet routing today. Internet autonomous systems (AS) possess fixed IP prefixes, while packets carry the intended destination AS's prefix in their headers, in clear text.
Barrineau, Geddings +5 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Software-Defined Information-Centric Network Architecture
Guangtongxin yanjiu, 2016 Existing proposals of Software-Defined Information-Centric Networking（SDICN）are difficult to support massive content delivery and to enable respective updates of switching and buffering components.This motivates us to propose an overlay-based SDICN ...
LI Keng, CHEN Jing-wen, JIANG Yu, MA Lin
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source