Results 71 to 80 of about 23,629 (241)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The Influence of Failover on Software-Defined Network and Conventional Network
Journal of Internet and Software Engineering, 2020 The growing use of the Internet resulted in the number of agencies that use two or more internet gateway paths or so-called Internet Service Providers (ISPs) to maintain network availability. Using two or more gateway paths allows break-up of connections
Riffat Hasan Saputra, Alif Subardono
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
This project explores the implementation of a Software-Defined Networking(SDN) topology using Mininet to demonstrate the principles of centralized network control and programmability.
Sherwin Sathish
core +2 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Research on Software Defined Network Application in Optical Transmission Network
Dianxin kexue, 2013 In order to study the feasibility of software defined network（SDN）application in optical transmission network, the concept and background of SDN were presented, the drivers and issues of the application of SDN in optical transport networks were analyzed,
Yunbo Li, Han Li, Sheng Liu
doaj +2 more sources
Assessing the risk of violating SLA dependability requirements in software-defined networks [PDF]
, 2017 Dependability of computer and communication networks is an important aspect of the customer-provider relationship in the telecommunication industry. Considering the increasing interest in Software-Defined Networking (SDN) technologies, as well as unclear
Bjarne E. Helvik +7 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
A Software-Defined Information-Centric Network Architecture
Guangtongxin yanjiu, 2016 Existing proposals of Software-Defined Information-Centric Networking（SDICN）are difficult to support massive content delivery and to enable respective updates of switching and buffering components.This motivates us to propose an overlay-based SDICN ...
LI Keng, CHEN Jing-wen, JIANG Yu, MA Lin
doaj
On the security of software-defined next-generation cellular networks
, 2016 In the recent years, mobile cellular networks are ndergoing fundamental changes and many established concepts are being revisited. Future 5G network architectures will be designed to employ a wide range of new and emerging technologies such as Software ...
Vasilakis, Vasileios +4 more
core