Results 91 to 100 of about 23,629 (241)

Infinite cacheflow in software-defined networks

open access: yes, 2013
Software-Defined Networking (SDN) enables fine-grained poli-cies for firewalls, load balancers, routers, traffic monitoring, and other functionality. While Ternary Content Address-able Memory (TCAM) enables OpenFlow switches to pro-cess packets at high ...
Katta, Naga   +7 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Some Controversial Opinions on Software-Defined Data Plane Services [PDF]

open access: yes, 2013
Several recent proposals, namely Software Defined Networks (SDN), Network Functions Virtualization (NFV) and Network Service Chaining (NSC), aim to transform the network into a programmable platform, focusing respectively on the control plane (SDN) and ...
Nemirovsky, M.   +7 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Software Defined User Centric 5G Wireless Network Framework

open access: yesDianxin kexue, 2015
The radio access network of 5G is a complex heterogeneous network.The independence of different protocols limits the network performance. To unify the management of the heterogeneous network and provide personalized service,a software defined user ...
Hua Qu   +4 more
doaj   +2 more sources

SDWAN (Software Defined-WAN) Technology Evaluation and Implementation

open access: yes, 2020
Many organizations are struggling to provide high bandwidth and reliable internet connectivity at their branch offices and business locations and getting the most out of their operational expense.
Dr. Anshuman Awasthi
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

A Fault-Tolerant Consensus Protocol for Software-Defined Networks

open access: yes, 2019
Unlike traditional networking structures, the new-generation software-defined network (SDN) separates the network control and forwarding and enables the network control to be software programmable, making flexible and convenient management a key feature ...
Chien-Fu Cheng   +2 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

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