Results 81 to 90 of about 23,629 (241)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

AutoSecSDNDemo: Demonstration of automated end-to-end security in software-defined networks

, 2016
S.347-348The complexity of modern communication networks and innovative cyber-attacking methods make it difficult to automatically detect and prevent attacks. Software-Defined Networking (SDN) separates the forwarding of network traffic from the decision
Nils Gruschka, Kpatcha Bayarou, Rahamatullah Khondoker, Khondoker, Rahamatullah, Senf, Daniel, Pedro Larbig, Bayarou, Kpatcha, Gruschka, Nils, Daniel Senf, Larbig, Pedro   +9 more
core   +1 more source

Software defined network emulation with OpenFlow protocol

, 2020
In software defined network the network infrastructure layer where the entire network devices, like switches and routers reside is connected with the separate controller layer with the help of standard called OpenFlow.
Tsehay Admassu Assegie, Assegie, Tsehay Admassu   +1 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Software-Defined Network Overlays

, 2015
Software-defined networking (SDN) is a new paradigm that promises to revolutionize the operation of networks. By proposing a separation of the data-plane from the control plane and transferring all control plane operations to a centralized controller ...
Oluwamayowa A. Adeleke (7977236)
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Software defined airborne tactical network for aeronautic swarm

Tongxin xuebao, 2017
Aeronautic swarm was a new kind of aeronautic operationa1 system inspired by bio1ogica1 swarm behaviors.Whi1e 1eading to a new usage way of future aeronautic operationa1 resources，aeronautic swarm wou1d bring new cha11enges to the airborne tactica1 ...
Shang-hong ZHAO, Ke-fan CHEN, Na LYU, Xiang WANG, Jing ZHAO   +4 more
doaj   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Crossfire Attack Defense Method Based on Software Defined Network [PDF]

Jisuanji gongcheng
Unlike conventional Distributed Denial of Service(DDoS) attacks, Crossfire attacks launched by botnets are low-speed and indistinguishable, making them difficult for traditional intrusion detection systems to defend against.
GUO Lei, JING Shan, WEI Liang, ZHAO Chuan
doaj   +1 more source

Software-defined datacenter network debugging [PDF]

, 2018
Software-defined Networking (SDN) enables flexible network management, but as networks evolve to a large number of end-points with diverse network policies, higher speed, and higher utilization, abstraction of networks by SDN makes monitoring and ...
Tammana, Praveen Aravind Babu
core