Results 81 to 90 of about 5,927,341 (295)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

The Role of Software-Defined Networking in Cellular Networks

open access: yesProceedings, 2019
In this paper, we discuss how SDN can contribute to enhance future cellular networks. We first present SDN and describe its characteristics. Then, we explore how SDN can be used to improve current cellular networks, analyzing the advantages and ...
Pablo Fondo-Ferreiro   +1 more
doaj   +1 more source

Design, Implementation and Evaluation of an In-House Controller for Software Defined Networking with Applications [PDF]

open access: yes, 2017
Over the past several decades, there has been a dramatic improvement in net- working technologies. Network devices and protocols are becoming more powerful and complex. The vertical structure of the network protocol layers also leads to a coupled control
Xu, Yiming
core  

Software-Defined Wireless Mesh Networking

open access: yes, 2022
S.1520-1535The combination of Software-Defined Networking (SDN) and Wireless Mesh Network (WMN) is challenging due to the different natures of both concepts. SDN describes networks with homogeneous, static and centralized controlled topologies.
Kessel, M.   +5 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Fast Recovery in Software-Defined Networks

open access: yes2014 Third European Workshop on Software Defined Networks, 2014
Although Software-Defined Networking and its implementation OpenFlow facilitate managing networks and enable dynamic network configuration, recovering from network failures in a timely manner remains non-trivial. The process of (a) detecting the failure, (b) communicating it to the controller and (c) recomputing the new shortest paths may result in an ...
Van Adrichem, N.L.M. (author)   +2 more
openaire   +5 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Programmable IP Service Gateway for Software-Defined Networking: Assisting Easy Composition of Service Overlays

open access: yes, 2013
Overlay networking makes it easy for users add new network functionalities while keeping existing Internet connectivity intact. This paper introduces SCONE (Service-COmposable InterNEt) as a networking service to facilitate the management of service ...
조진용, 이소연
core  

Software-Defined Time Sensitive Networks Configuration and Management

open access: yes, 2021
Deterministic real time networking is typically provided by dedicated fieldbus networks which prevents innovation due to their proprietary nature, inflexibility and high-cost.
Hamza Chahed   +3 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

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