Results 151 to 160 of about 20,481,216 (301)
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Improving deep learning based bluespotted ribbontail ray (Taeniura Lymma) recognition
Ecological InformaticsThis paper presents the novel task of bluespotted ribbontail (BR) ray (Taeniura lymma) recognition using deep learning based computer vision methods to enable the identification of specific individuals of this species. Mapping the specific individuals in
Avivit Levy +4 more
doaj +1 more source
Suboptimal prescribing behaviour associated with clinical software design features: a retrospective cohort study in English NHS primary care. [PDF]
Br J Gen Pract, 2020 MacKenna B +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Artifacts in Software Design [PDF]
, 1992 “A scientific discipline emerges with the — usually rather slow! — discovery of which aspects can be meaningfully ‘studied in isolation for the sake of their own consistency’.”1 This statement made by E.W. Dijkstra was meant to express a specific desire, namely, to achieve basic improvements in software development by means of mathematical tools and ...
openaire +2 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Sustainability Design and Software: The Karlskrona Manifesto [PDF]
Sustainability has emerged as a broad concern for society. Many engineering disciplines have been grappling with challenges in how we sustain technical, social and ecological systems.
Becker, Christoph +6 more
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source