Results 151 to 160 of about 21,707,590 (377)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Domain specific software design for decision aiding [PDF]

McDonnell Aircraft Company (MCAIR) is involved in many large multi-discipline design and development efforts of tactical aircraft. These involve a number of design disciplines that must be coordinated to produce an integrated design and a successful ...
Keller, Kirby, Stanley, Kevin
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Digital twin method and application practice of spacecraft system driven by mechanism data [version 2; peer review: 1 approved, 2 approved with reservations]

Digital Twin
Spacecrafts are large-scale systems characterized by various on-orbit configurations, multi-disciplinary coupling, and complex mission modes. Research and exploration on the data-driven spacecraft digital twins development methods must be carried out to ...
Zhou Fanli, Huang Lei, Shang Shuai, Wang Wei, Zhou Haocheng   +4 more
doaj   +1 more source

Collaborative Design and Planning of Software Architecture Changes via Software City Visualization [PDF]

Alexander Krause-Glau, Malte Hansen, Wilhelm Hasselbring   +2 more
openalex   +1 more source

Sustainability Design and Software: The Karlskrona Manifesto [PDF]

Sustainability has emerged as a broad concern for society. Many engineering disciplines have been grappling with challenges in how we sustain technical, social and ecological systems.
Becker, Christoph, Chitchyan, Ruzanna, Duboc, Leticia, Easterbrook, Steve, Penzenstadler, Birgit, Seyff, Norbert, Venters, Colin   +6 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Artifacts in Software Design [PDF]

, 1992
“A scientific discipline emerges with the — usually rather slow! — discovery of which aspects can be meaningfully ‘studied in isolation for the sake of their own consistency’.”1 This statement made by E.W. Dijkstra was meant to express a specific desire, namely, to achieve basic improvements in software development by means of mathematical tools and ...
openaire   +2 more sources

A Data Transformation Methodology to Create Findable, Accessible, Interoperable, and Reusable Health Data: Software Design, Development, and Evaluation Study.

J Med Internet Res, 2023
Sinaci AA, Gencturk M, Teoman HA, Laleci Erturkmen GB, Alvarez-Romero C, Martinez-Garcia A, Poblador-Plou B, Carmona-Pírez J, Löbe M, Parra-Calderon CL.   +9 more
europepmc   +1 more source

Suboptimal prescribing behaviour associated with clinical software design features: a retrospective cohort study in English NHS primary care. [PDF]

Br J Gen Pract, 2020
MacKenna B, Curtis HJ, Walker AJ, Bacon S, Croker R, Goldacre B.   +5 more
europepmc   +1 more source