Results 131 to 140 of about 14,237,440 (297)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Applied SciencesThis paper presents a geometry-driven framework for temporally stable 2D isoline reconstruction from particle-based simulation data. Unlike conventional Marching Squares methods, which assume grid-aligned scalar fields and often suffer from boundary ...
Yu-Bin Kwon, Jong-Hyun Kim
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, 1980 © 1980 California Institute of Technology. I wish to thank Dr. Frederick B. Thompson for his patient guidance and help during my graduate studies at Caltech.
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Using autonomous components to improve runtime qualities of software
, 2011 In the development of software systems, quality properties should be considered along with the development process so that the qualities of software systems can be inferred and predicted at the specification and design stages and be evaluated and ...
Jiao, W., W. Jiao
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
, 2017 A multi-agent-based software system for modelling and simulation of the value space of low carbon dioxide emission ...
Li, Shuliang, Zeng, Y.
core
TechnologiesCurrent approaches to dynamic sign language recognition commonly rely on dense landmark representations, which impose high computational cost and hinder real-time deployment on resource-constrained devices.
Gerardo Garcia-Gil +2 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source