Results 111 to 120 of about 2,895,022 (317)

Twelve quick tips for software design. [PDF]

open access: yesPLoS Comput Biol, 2022
Wilson G.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Reflective approach for software design decision making [PDF]

open access: yes, 2016
Good software design practice is difficult to define and teach. Despite the many software design methods and processes that are available, the quality of software design relies on human factors. We notice from literature and our own experiments that some
Lago, Patricia   +13 more
core   +1 more source

Updating Model of Software Component Trustworthiness Based on Users Feedback

open access: yesIEEE Access, 2019
The software trustworthiness measurement is one of the hot topics. Software component technology is the mainstream technology of software development.
Baohua Wang   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Expertise in software design : novice and expert models [PDF]

open access: yes, 2010
This paper investigates how software designers use their knowledge during the design process. The research is based on the analysis of the observational and verbal data from three software design teams generated during the conceptual stage of the design ...
Kraal, Ben J., Popovic, Vesna
core  

Systematic evaluation of design choices for software development tools [PDF]

open access: yes, 1998
[Abstract]: Most design and evaluation of software tools is based on the intuition and experience of the designers. Software tool designers consider themselves typical users of the tools that they build and tend to subjectively evaluate their products ...
Welsh, Jim, Toleman, Mark
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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