Results 111 to 120 of about 14,237,440 (297)

Aspects and Objects: A Unified Software Design Framework [PDF]

Aspect-Oriented Software Development provides a means to modularize concerns of a system which are scattered over multiple system modules. These concerns are known as crosscutting concerns and they cause code to be scattered and tangled in multiple ...
Iqbal, Saqib
core   +3 more sources

Design and Implementation of a Musical System for the Development of Creative Activities Through Electroacoustics in Educational Contexts

Signals
In the field of music education, the incorporation of technology originally designed for professionals presents both significant opportunities and challenges.
Esteban Peris, Adolf Murillo, Jesús Tejada   +2 more
doaj   +1 more source

A Data Transformation Methodology to Create Findable, Accessible, Interoperable, and Reusable Health Data: Software Design, Development, and Evaluation Study. [PDF]

J Med Internet Res, 2023
Sinaci AA, Gencturk M, Teoman HA, Laleci Erturkmen GB, Alvarez-Romero C, Martinez-Garcia A, Poblador-Plou B, Carmona-Pírez J, Löbe M, Parra-Calderon CL.   +9 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Variability-Aware Machine Learning Model Selection: Feature Modeling, Instantiation, and Experimental Case Study

IEEE Access
The emergence of machine learning (ML) has led to a transformative shift in software techniques and guidelines for building software applications that support data analysis process activities such as data ingestion, modeling, and deployment. Specifically,
Cristina Tavares, Nathalia Nascimento, Paulo Alencar, Donald Cowan   +3 more
doaj   +1 more source

A user task design notation for improved software design. [PDF]

PeerJ Comput Sci, 2021
Ozcan E, Topalli D, Tokdemir G, Cagiltay NE.   +3 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Design of neurophysiological signal analysis software [PDF]

, 2010
Recenti sviluppi tecnologici permettono registrazioni sempre più accurate dell’attività neuronale. Diversi laboratori hanno sviluppato programmi per l’analisi di tali dati, ma tuttora non esiste alcun software che fornisca un supporto completo per l ...
Bassetto , Giacomo
core  

[Model construction and software design of computed tomography radiation system based on visualization]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2023
Liu Y, Meng T, Zhang H, Lu H.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source