Results 101 to 110 of about 2,895,022 (317)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

PLM and early stages collaboration in interactive design, a case study in the glass industry [PDF]

open access: yes, 2014
Product design activity is traditionally presented as a succession of four to six stages. In the early stages of design, during the search for concepts, multi-disciplinary teams are working together, sometimes on the fringe of the digital design chain ...
VERON, Philippe, SEGONDS, Frederic
core   +1 more source

Dual modality prompt learning for visual question-grounded answering in robotic surgery

open access: yesVisual Computing for Industry, Biomedicine, and Art
With recent advancements in robotic surgery, notable strides have been made in visual question answering (VQA). Existing VQA systems typically generate textual answers to questions but fail to indicate the location of the relevant content within the ...
Yue Zhang   +5 more
doaj   +1 more source

Ageing as a software design flaw. [PDF]

open access: yesGenome Biol, 2023
de Magalhães JP.
europepmc   +1 more source

Self-Designing Software

open access: yesCommunications of the ACM
Exploring ways to include a software system as an active member of its own design team, able to reason about its own design and to synthesize better variants of its own building blocks as it encounters different deployment conditions.
Barry Porter   +2 more
openaire   +1 more source

Traceability and modularity in software design [PDF]

open access: yesProceedings Ninth International Workshop on Software Specification and Design, 2002
A software design specification consists of a number of documents that describe various aspect of the design at different levels of detail, that are linked in many ways. This paper shows how different designs may use different modularization criteria, and how documents describing these designs may be linked in a coherent way, even if the designs use ...
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Resolving Architectural Mismatches of COTS Through Architectural Reconciliation [PDF]

open access: yes, 2005
The integration of COTS components into a system under development entails architectural mismatches. These have been tackled, so far, at the component level, through component adaptation techniques, but they also must be tackled at an architectural level
Guelfi, Nicolas   +6 more
core   +1 more source

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