Results 101 to 110 of about 14,237,440 (297)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Twelve quick tips for software design. [PDF]
PLoS Comput Biol, 2022 Wilson G.
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Where's the theory for software engineering?
, 2012 Software engineering is a practical engineering discipline without scientific ambitions where rules of thumb and guidelines assume the role of theory. Most of the theories are casual, proposed by the authors but rarely subjected to extended studies, and ...
Jacobson, Ivar +5 more
core +1 more source
Facilitating the comprehension of human-computer interaction design intent within a software team [PDF]
, 1998 A large proportion of today’s software development is unsuccessful. One reason for this is thought to be lack of attention to the user. Maintaining a user-centred focus during software production is regarded as a major problem.
Myhill, Carl
core +3 more sources
Insights from a dataset on behavioral intentions in learning information flow diagram capability for software design. [PDF]
Data Brief, 2023 Rukhiran M, Chomngern T, Netinant P.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Updating Model of Software Component Trustworthiness Based on Users Feedback
IEEE Access, 2019 The software trustworthiness measurement is one of the hot topics. Software component technology is the mainstream technology of software development.
Baohua Wang +3 more
doaj +1 more source
A Survey on Autism Care, Diagnosis, and Intervention Based on Mobile Apps Focusing on Usability and Software Design. [PDF]
Sensors (Basel), 2023 Liu X, Zhao W, Qi Q, Luo X.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source