Results 81 to 90 of about 6,316,092 (301)

An initial performance review of software components for a heterogeneous computing platform

open access: yes, 2016
The design of embedded systems is a complex activity that involves a lot of decisions. With high performance demands of present day usage scenarios and software, they often involve energy hungry state-of-the-art computing units.
Švogor, Ivan
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The design of software interfaces in Spec [PDF]

open access: yesProceedings. 1988 International Conference on Computer Languages, 2003
Spec, a language for giving black-box specifications in the early stages of software design is presented. The underlying computational model combines message passing with temporal events in a precisely defined way. The features of the language, especially those important for large-scale design, are presented by example. >
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Utilizing FM software in collaborative design-learning

open access: yes, 2008
In this paper, we describe a case study of computer-supported collaborative learning in design using OpenLearn FlashMeeting software, a video conferencing tool.
Ferreira, Giselle   +2 more
core  

What to Fix? Distinguishing between design and non-design rules in automated tools

open access: yes, 2017
Technical debt---design shortcuts taken to optimize for delivery speed---is a critical part of long-term software costs. Consequently, automatically detecting technical debt is a high priority for software practitioners.
Bellomo, Stephany   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Altimeter waveform software design [PDF]

open access: yes
Techniques are described for preprocessing raw return waveform data from the GEOS-3 radar altimeter. Topics discussed include: (1) general altimeter data preprocessing to be done at the GEOS-3 Data Processing Center to correct altimeter waveform data for
Brown, G. S.   +2 more
core   +1 more source

Application Software, Domain-Specific Languages, and Language Design Assistants [PDF]

open access: yes, 2000
While application software does the real work, domain-specific languages (DSLs) are tools to help produce it efficiently, and language design assistants in turn are meta-tools to help produce DSLs quickly. DSLs are already in wide use (HTML for web pages,
Heering, Jan
core   +2 more sources

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