Results 71 to 80 of about 2,532,329 (269)
Communications of the ACMExploring ways to include a software system as an active member of its own design team, able to reason about its own design and to synthesize better variants of its own building blocks as it encounters different deployment conditions.
Barry Porter +2 more
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Control Software Design for a Multisensing Multicellular Microscale Gas Chromatography System. [PDF]
Micromachines (Basel), 2023 Xu Q, Zhao X, Qin Y, Gianchandani YB.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Twelve quick tips for software design. [PDF]
PLoS Comput Biol, 2022 Wilson G.
europepmc +1 more source
Traceability and modularity in software design [PDF]
Proceedings Ninth International Workshop on Software Specification and Design, 2002 A software design specification consists of a number of documents that describe various aspect of the design at different levels of detail, that are linked in many ways. This paper shows how different designs may use different modularization criteria, and how documents describing these designs may be linked in a coherent way, even if the designs use ...
openaire +3 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Insights from a dataset on behavioral intentions in learning information flow diagram capability for software design. [PDF]
Data Brief, 2023 Rukhiran M, Chomngern T, Netinant P.
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source