Results 71 to 80 of about 14,237,440 (297)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
09432 Report – Quantitative Software Design [PDF]
, 2010 Between 20.10.09 and 23.10.09, the Dagstuhl Seminar 09432, Quantitative Software Design, was held at the International Conference and Research Center (IBFI), Schloss Dagstuhl. Quantitative software design is a field of research that is not yet firmly
Poernomo, Iman +2 more
core +1 more source
TechnologiesEffective communication is crucial in daily life, and for people with hearing disabilities, sign language is no exception, serving as their primary means of interaction. Various technologies, such as cochlear implants and mobile sign language translation
Gerardo García-Gil +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Replication Package: Modular Extra-functional Analysis of Software Architectural Design Models
, 2022 This is the replication package of the paper titled "Modular Extra-functional Analysis of Software Architectural Design Models" and submitted for revision to ECSA 2022.
Anonymous Authors (5249489)
core +1 more source
Evidence-based Tool for Triggering School Closures during Influenza Outbreaks, Japan
Emerging Infectious Diseases, 2009 Guidelines available to school administrators to support school closure decisions during influenza outbreaks are usually not evidence-based. Using empirical data on absentee rates of elementary school students in Japan, we developed a simple and ...
Asami Sasaki +7 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Looking back or looking forward in corpus linguistics: What can the last 20 years suggest about the next? [PDF]
Ibérica, 2012 Starting with a description of the software and hardware used for corpus linguistics in the late 1980s to early 1990s, this contribution discusses difficulties faced by the software designer when attempting to allow users to study text.
Mike Scott
doaj
Communications of the ACMExploring ways to include a software system as an active member of its own design team, able to reason about its own design and to synthesize better variants of its own building blocks as it encounters different deployment conditions.
Barry Porter +2 more
openaire +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source