Results 71 to 80 of about 2,895,022 (317)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Support for evolving software architectures in the ArchWare ADL [PDF]
, 2011 Software that cannot evolve is condemned to atrophy: it cannot accommodate the constant revision and re-negotiation of its business goals nor intercept the potential of new technology.
Balasubramaniam, Dharini +17 more
core +1 more source
TechnologiesEffective communication is crucial in daily life, and for people with hearing disabilities, sign language is no exception, serving as their primary means of interaction. Various technologies, such as cochlear implants and mobile sign language translation
Gerardo García-Gil +4 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Towards Building a Uniform Cloud Database Representation for Data Interchange
Annals of the West University of Timisoara: Mathematics and Computer Science, 2016 The paper proposes design principles for data representation and simplification in order to design cloud services for data exchange between various information systems. We use equivalence algorithms and canonical representation in the cloud database. The
Andreica Alina
doaj +1 more source
Bellini’s Correspondence: a Digital Scholarly Edition for a Multimedia Museum
Umanistica Digitale, 2019 Within the “Museo Virtuale della Musica BellinInRete” project, a corpus of letters, written by the renowned composer Vincenzo Bellini (1801 - 1835) from Catania, will be encoded and made publicly available. This contribution aims at illustrating the part
Angelo Mario Del Grosso +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Facilitating the comprehension of human-computer interaction design intent within a software team [PDF]
, 1998 A large proportion of today’s software development is unsuccessful. One reason for this is thought to be lack of attention to the user. Maintaining a user-centred focus during software production is regarded as a major problem.
Myhill, Carl
core
Towards an Analytical Approach to Measure Modularity in Software Architecture Design [PDF]
, 2015 Modularization is one of the important subjects in the software design area which leads to increasing the level of quality attributes such as maintainability, portability, reusability, interoperability and flexibility.
M. Ghasemi, S. Mehran Sharafi, A. Arman
core +1 more source
Artifacts in Software Design [PDF]
, 1992 “A scientific discipline emerges with the — usually rather slow! — discovery of which aspects can be meaningfully ‘studied in isolation for the sake of their own consistency’.”1 This statement made by E.W. Dijkstra was meant to express a specific desire, namely, to achieve basic improvements in software development by means of mathematical tools and ...
openaire +2 more sources