Results 51 to 60 of about 2,532,329 (269)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A robust watermarking algorithm against JPEG compression based on multiscale autoencoder

open access: yesIET Image Processing
The network structure of digital watermarking algorithm based on deep learning is usually encoder‐noise layer‐decoder. Most of the existing encoders suffer from the problem of insufficient feature extraction, and the introduction of simulated ...
Wei Zhang, Rongrong Chen, Bin Wang
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Real-Time Machine Learning for Accurate Mexican Sign Language Identification: A Distal Phalanges Approach

open access: yesTechnologies
Effective communication is crucial in daily life, and for people with hearing disabilities, sign language is no exception, serving as their primary means of interaction. Various technologies, such as cochlear implants and mobile sign language translation
Gerardo García-Gil   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Evidence-based Tool for Triggering School Closures during Influenza Outbreaks, Japan

open access: yesEmerging Infectious Diseases, 2009
Guidelines available to school administrators to support school closure decisions during influenza outbreaks are usually not evidence-based. Using empirical data on absentee rates of elementary school students in Japan, we developed a simple and ...
Asami Sasaki   +7 more
doaj   +1 more source

Artifacts in Software Design [PDF]

open access: yes, 1992
“A scientific discipline emerges with the — usually rather slow! — discovery of which aspects can be meaningfully ‘studied in isolation for the sake of their own consistency’.”1 This statement made by E.W. Dijkstra was meant to express a specific desire, namely, to achieve basic improvements in software development by means of mathematical tools and ...
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Looking back or looking forward in corpus linguistics: What can the last 20 years suggest about the next? [PDF]

open access: yesIbérica, 2012
Starting with a description of the software and hardware used for corpus linguistics in the late 1980s to early 1990s, this contribution discusses difficulties faced by the software designer when attempting to allow users to study text.
Mike Scott
doaj  

On regularity in software design

open access: yesScience of Computer Programming, 1995
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

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