Results 51 to 60 of about 6,316,092 (301)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Hip joint contact forces and muscle contributions between bounce and standard squats
BMC Sports Science, Medicine and RehabilitationBackground Bounce squats, involving a rapid eccentric-concentric transition, are used in strength training to enhance force production via the stretch-shortening cycle.
Taewoong Kong +4 more
doaj +1 more source
A Model for Quality Optimization in Software Design Processes [PDF]
, 2005 The main objective of software engineers is to design and implement systems that implement all functional and non-functional requirements. Unfortunately, it is very difficult or even generally impossible to deliver a software system that satisfies all ...
Aksit, Mehmet +2 more
core +1 more source
On regularity in software design
Science of Computer Programming, 1995 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Embedding object-oriented design in system engineering [PDF]
, 1999 The Unified Modeling Language (UML) is a collection of techniques intended to document design decisions about software. This contrasts with systems engineering approaches such as for exampleStatemate and the Yourdon Systems Method (YSM), in which the ...
D Harel, RJ Wieringa
core +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Domain-oriented architecture design for production control software [PDF]
, 1998 this paper, we present domain-oriented architectural design heuristics for production control software. Our approach is based upon the following premisses.
Engmann, Rolf +2 more
core +2 more sources
Adaptive development and maintenance of user-centric software systems [PDF]
, 2004 A software system cannot be developed without considering the various facets of its environment. Stakeholders – including the users that play a central role – have their needs, expectations, and perceptions of a system.
Alspaugh +24 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source