Results 41 to 50 of about 2,895,022 (317)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Software Design Guidelines for Usability [PDF]

open access: yes, 2011
For years, the Human Computer Interaction (HCI) community has crafted usability guidelines that clearly define what characteristics a software system should have in order to be easy to use.
Carvajal García, Laura Elena   +1 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The integration of software specification, verification, and testing techniques with software requirements and design processes. [PDF]

open access: yes, 1995
Specifying, verifying, and testing software requirements and design are very important tasks in the software development process and must be taken seriously.
Chantatub, Wachara
core  

A Platform-Based Software Design Methodology for Embedded Control Systems: An Agile Toolkit [PDF]

open access: yes, 2008
A discrete control system, with stringent hardware constraints, is effectively an embedded real-time system and hence requires a rigorous methodology to develop the software involved.
Carlos Mar   +14 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Korean WA-DGNSS User Segment Software Design [PDF]

open access: yesTransNav, 2013
Korean WA-DGNSS is a large scale research project funded by Ministry of Land, Transport and Maritime Affairs Korea. It aims to augment the Global Navigation Satellite System by broadcasting additional signals from geostationary satellites and providing ...
Sayed Chhattan Shah   +4 more
doaj   +1 more source

Image Encryption Scheme Based on Multiscale Block Compressed Sensing and Markov Model

open access: yesEntropy, 2021
Many image encryption schemes based on compressed sensing have the problem of poor quality of decrypted images. To deal with this problem, this paper develops an image encryption scheme by multiscale block compressed sensing. The image is decomposed by a
Yuandi Shi, Yinan Hu, Bin Wang
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Using autonomous components to improve runtime qualities of software [PDF]

open access: yes, 2011
In the development of software systems, quality properties should be considered along with the development process so that the qualities of software systems can be inferred and predicted at the specification and design stages and be evaluated and ...
Jiao, W., W. Jiao
core   +1 more source

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