Results 91 to 100 of about 14,237,440 (297)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
A Search-Based Approach to Multi-view Clustering of Software Systems [PDF]
, 2015 —Unsupervised software clustering is the problem of automatically decomposing the software system into meaningful units. Some approaches solely rely on the structure of the system, such as the module dependency graph, to decompose the software systems ...
Hage, J.; id_orcid +14 more
core +2 more sources
Artifacts in Software Design [PDF]
, 1992 “A scientific discipline emerges with the — usually rather slow! — discovery of which aspects can be meaningfully ‘studied in isolation for the sake of their own consistency’.”1 This statement made by E.W. Dijkstra was meant to express a specific desire, namely, to achieve basic improvements in software development by means of mathematical tools and ...
openaire +2 more sources
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Stable and predictable Voronoi treemaps for software quality monitoring [PDF]
, 2017 Context: Voronoi treemaps can be used to effectively visualize software quality attributes of a given software system. Algorithms for computing Voronoi treemaps are non-deterministic making them unsuited for monitoring the development of such attributes ...
Hage, J.; id_orcid +4 more
core +2 more sources
On regularity in software design
Science of Computer Programming, 1995 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +4 more sources
Traceability and modularity in software design [PDF]
Proceedings Ninth International Workshop on Software Specification and Design, 2002 A software design specification consists of a number of documents that describe various aspect of the design at different levels of detail, that are linked in many ways. This paper shows how different designs may use different modularization criteria, and how documents describing these designs may be linked in a coherent way, even if the designs use ...
openaire +3 more sources
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Control Software Design for a Multisensing Multicellular Microscale Gas Chromatography System. [PDF]
Micromachines (Basel), 2023 Xu Q, Zhao X, Qin Y, Gianchandani YB.
europepmc +1 more source