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Object-Oriented Simulation Model Generation in an Automated Control Software Development Framework [PDF]

open access: yes, 2009
Organised by: Cranfield UniversityThe automated development of control software for mechatronic systems requires the integration of control models for design and verification purposes.
van Tooren, M. J. L., Foeken, M. J.
core  

Understanding and Supporting Software Design in Model-Based Software Engineering [PDF]

open access: yes, 2020
Model-Based Software Engineering (MBSE) is a software development approach in which models can serve a multitude of purposes. On the one hand, models can be used for ideation, to stimulate creative thinking, and facilitate communication.
Jolak, Rodi
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Concurrent design of embedded control software [PDF]

open access: yes, 2009
Embedded software design for mechatronic systems is becoming an increasingly time-consuming and error-prone task. In order to cope with the heterogeneity and complexity, a systematic model-driven design approach is needed, where several parts of the ...
Voeten, J.P.M.   +7 more
core   +2 more sources

PartiEMC: Stable Isoline Reconstruction from Particle-Based Scalar Fields via Virtual-Plane Projection

open access: yesApplied Sciences
This paper presents a geometry-driven framework for temporally stable 2D isoline reconstruction from particle-based simulation data. Unlike conventional Marching Squares methods, which assume grid-aligned scalar fields and often suffer from boundary ...
Yu-Bin Kwon, Jong-Hyun Kim
doaj   +1 more source

The design of software interfaces in Spec [PDF]

open access: yesProceedings. 1988 International Conference on Computer Languages, 2003
Spec, a language for giving black-box specifications in the early stages of software design is presented. The underlying computational model combines message passing with temporal events in a precisely defined way. The features of the language, especially those important for large-scale design, are presented by example. >
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Contribuições do design na produção de software educacional [PDF]

open access: yes, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de ProduçãoO presente trabalho apresenta as contribuições que o design pode oferecer ao desenvolvimento de softwares educacionais.
Fenner, Rita de Cássia
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Sustainability Design and Software: The Karlskrona Manifesto [PDF]

open access: yes
Sustainability has emerged as a broad concern for society. Many engineering disciplines have been grappling with challenges in how we sustain technical, social and ecological systems.
Penzenstadler, Birgit   +6 more
core  

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