Results 121 to 130 of about 2,895,022 (317)

Small scale software engineering [PDF]

, 1981
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In computing, the Software Crisis has arisen because software projects cannot meet their planned timescales, functional capabilities, reliability levels and
Witty, Robert W
core  

A Data Transformation Methodology to Create Findable, Accessible, Interoperable, and Reusable Health Data: Software Design, Development, and Evaluation Study. [PDF]

J Med Internet Res, 2023
Sinaci AA, Gencturk M, Teoman HA, Laleci Erturkmen GB, Alvarez-Romero C, Martinez-Garcia A, Poblador-Plou B, Carmona-Pírez J, Löbe M, Parra-Calderon CL.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Aspects and Objects: A Unified Software Design Framework [PDF]

Aspect-Oriented Software Development provides a means to modularize concerns of a system which are scattered over multiple system modules. These concerns are known as crosscutting concerns and they cause code to be scattered and tangled in multiple ...
Iqbal, Saqib
core  

A user task design notation for improved software design. [PDF]

PeerJ Comput Sci, 2021
Ozcan E, Topalli D, Tokdemir G, Cagiltay NE.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Democratizing Software Design Through Functional Individualization of Creative Software [PDF]

, 2017
The evolution of creative software is informed by the traditional computer-science methods of development. This results in creation of generic software with task-oriented perspective. User testing data and feedback that sampled from different individuals

core   +1 more source

Design and Implementation of a Musical System for the Development of Creative Activities Through Electroacoustics in Educational Contexts

Signals
In the field of music education, the incorporation of technology originally designed for professionals presents both significant opportunities and challenges.
Esteban Peris, Adolf Murillo, Jesús Tejada   +2 more
doaj   +1 more source

[Model construction and software design of computed tomography radiation system based on visualization]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2023
Liu Y, Meng T, Zhang H, Lu H.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source