Results 191 to 200 of about 7,204,729 (322)

Sustainable software development in science - insights from 20 years of Vanted. [PDF]

open access: yesJ Integr Bioinform
Schreiber F   +7 more
europepmc   +1 more source

GrimoireLab: A toolset for software development analytics. [PDF]

open access: yesPeerJ Comput Sci, 2021
Dueñas S   +6 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

AI-driven cybersecurity framework for software development based on the ANN-ISM paradigm. [PDF]

open access: yesSci Rep
Khan HU   +5 more
europepmc   +1 more source

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