Results 141 to 150 of about 4,946,816 (331)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
THE ROLE OF INFOGRAPHIC TECHNOLOGY IN THE EDUCATIONAL PROCESS AND SOFTWARE TOOLS FOR ITS DEVELOPMENT
, 2022 M.Ibaydullayev D.Sultonova
openalex +1 more source
An Exploratory Study Gathering Security Requirements for the Software Development Process [PDF]
, 2023 Roberto Andrade +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
DESIGN OF THE APPLICATION FOR MANAGEMENT OF SOFTWARE DEVELOPMENT PROCESSES
, 2023 O Bezverkhiy +5 more
openalex +1 more source
Software Development Processes Maturity Versus Software Processes And Products Measurement
, 2012 Unsatisfactory effectiveness of software systems development and enhancement projects is one of the main reasons why in software engineering there are attempts being made to use experiences coming from other engineering disciplines. In spite of specificity of software product and process a belief had come out that the execution of software could be ...
openaire +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
TAILORING AND IMPLEMENTATION OF AN AGILE SOFTWARE DEVELOPMENT PROCESS
Havacılık ve Uzay Teknolojileri Dergisi, 2010 In 1990s, a new software development approach named “agile”, suggested new methodologies for projects of relatively short duration and changing requirements.
Kadir ÇAMOĞLU +3 more
doaj
Creating a Business Process Monitoring System“A-IOMS” for Software Development
, 2012 openalex +1 more source