Results 191 to 200 of about 2,063,829 (266)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A guide for the deployment, validation, and accreditation of clinical digital pathology tools. [PDF]

J Pathol Inform
Janowczyk A, Ferrari J, Brandt N, Padayachy L, Bornand A, Chartier S, Mallet T, Roduit N, Seed P, Tekes Mizrakli M, Massonnet J, Liakopoulos P, Braunersreuther V, Kreutzfeldt M, Rubbia-Brandt L, Merkler D.   +15 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Software engineering for reproducible pipeline development in bioinformatics. [PDF]

Front Bioinform
Pérez-Rodríguez D, Nogueira-Rodríguez A, Vieira J, Vieira CP, Glez-Peña D, López-Fernández H.   +5 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Digital infrastructure to support and share daily high-throughput experimental materials research.

Faraday Discuss
Mittmann LA, Nässtrom H, Bertin E, Kapoor S, Diogo I, Itzhak A, Dalmonte G, Danielsen RT, Skytte ME, von Wenckstern H, Crovetto A, Márquez JA.   +11 more
europepmc   +1 more source

Intelligent Parameter Tuning Strategy for Nuclear Power Simulation Systems Based on Soft Actor-Critic. [PDF]

Entropy (Basel)
Lu X, Liu Z, Li X, Xiong Y, Luo J, Zhou H.   +5 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Harnessing Methylselenol (CH₃SeH): A Highly Effective Platform for Stimuli-Responsive Delivery With Therapeutic Potential. [PDF]

Adv Sci (Weinh)
Liang W, Wang L, Wang X, Li X, Xing H, Sun L, Xi Z, Yi L.   +7 more
europepmc   +1 more source

The Effectiveness of Geographic Information Systems in Social Studies Education: A Mixed-Meta Synthesis of Academic Achievement and Qualitative Learning Outcomes. [PDF]

J Intell
Erbaş AA, Evci N, Akcan C, Akcan E, Yeşiltaş E.   +4 more
europepmc   +1 more source