Results 41 to 50 of about 76,374 (267)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
IEEE AccessThe success of software projects is closely linked to accurate effort estimation, driving continuous efforts by researchers to refine estimation methods.
Taghi Javdani Gandomani +3 more
doaj +1 more source
A New Approach to Calibrating Functional Complexity Weight in Software Development Effort Estimation
Computers, 2022 Function point analysis is a widely used metric in the software industry for development effort estimation. It was proposed in the 1970s, and then standardized by the International Function Point Users Group, as accepted by many organizations worldwide ...
Vo Van Hai +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Automatika, 2023 In recent years, many researchers and software industries have given significant attention to the estimation of software effort. Software effort estimation is a challenge that often appears in the project of making software.
A. Salinda Eveline Suniram, J. Charles
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Estimating software project effort using analogies [PDF]
IEEE Transactions on Software Engineering, 1997 Accurate project effort prediction is an important goal for the software engineering community. To date most work has focused upon building algorithmic models of effort, for example COCOMO. These can be calibrated to local environments. We describe an alternative approach to estimation based upon the use of analogies.
M. Shepperd, C. Schofield
openaire +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Software Cost and Effort Estimation: Current Approaches and Future Trends
IEEE Access, 2023 Software cost and effort estimation is one of the most significant tasks in the area of software engineering. Research conducted in this field has been evolving with new techniques that necessitate periodic comparative analyses.
Chaudhary Hamza Rashid +6 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source