Results 41 to 50 of about 83,073 (313)

Improving Effort Estimation by Voting Software Estimation Models [PDF]

Advances in Software Engineering, 2009
Estimating software development effort is an important task in the management of large software projects. The task is challenging, and it has been receiving the attentions of researchers ever since software was developed for commercial purpose. A number of estimation models exist for effort prediction.
Capretz, Luiz Fernando, Marza, Venus
openaire   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A systematic review of software development cost estimation studies

, 2007
This paper aims to provide a basis for the improvement of software estimation research through a systematic review of previous work. The review identifies 304 software cost estimation papers in 76 journals and classifies the papers according to research ...
Shepperd, MJ, Jørgensen, M
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

AI-Based Models for Software Effort Estimation

2010 36th EUROMICRO Conference on Software Engineering and Advanced Applications, 2010
Decision making under uncertainty is a critical problem in the field of software engineering. Predicting the software quality or the cost/ effort requires high level expertise. AI based predictor models, on the other hand, are useful decision making tools that learn from past projects' data. In this study, we have built an effort estimation model for a
Ekrem Kocaguneli, Ayse Tosun, Ayse Basar Bener   +2 more
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Effort estimation of FLOSS projects: A study of the Linux kernel

, 2011
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 SpringerEmpirical research on Free/Libre/Open Source Software (FLOSS) has shown that developers tend to cluster around ...
Izquierdo-Cortazar, D, Daniel Izquierdo-Cortázar, Andrea Capiluppi, Capiluppi, A   +3 more
core   +1 more source

Enhanced framework for ensemble effort estimation by using recursive‐based classification

IET Software, 2021
Service‐oriented software engineering is a software engineering methodology focussed on the development of software systems. The systematic application of technological and scientific knowledge depends on the methodology, experience, design for obtaining
Azath Hussain, Maheswari Raja, Pandimurugan Vellaisamy, Sangeetha Krishnan, Lakshminarayanan Rajendran   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hybrid effort estimation of changes in agile software development

, 2022
S.316-320Unlike traditional software development approaches, Agile embraces change. The resulting dynamism of requirements makes it challenging to estimate effort accurately.
Tanveer, Binish
core   +1 more source