Results 91 to 100 of about 7,830,371 (321)

Variability and Evolution in Systems of Systems

, 2013
In this position paper (1) we discuss two particular aspects of Systems of Systems, i.e., variability and evolution. (2) We argue that concepts from Product Line Engineering and Software Evolution are relevant to Systems of Systems Engineering.
Botterweck, Goetz
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Developing an undergraduate software engineering degree [PDF]

, 2003
As those who have done it can attest, developing an undergraduate degree in software engineering is a daunting and challenging task, and there have been instances where a department has tried, but failed to get its program approved.
Armarego, J., Bagert, D.J., Eisenbach, S., Hilburn, T.B., Naveda, J.F., Seidman, S.   +5 more
core   +1 more source

On the Presence of Green and Sustainable Software Engineering in Higher Education Curricula

, 2017
Nowadays, software is pervasive in our everyday lives. Its sustainability and environmental impact have become major factors to be considered in the development of software systems. Millennials-the newer generation of university students-are particularly
Fucci, Davide, Lutovac, Sonja, Procaccianti, Giuseppe, Scanniello, Giuseppe, Torre, Damiano   +4 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

THE PLACE AND ROLE OF KNOWLEDGE MANAGEMENT IN A SUSTAINABLE ORGANIZATION FROM THE SOFTWARE ENGINEERING BRANCH [PDF]

, 2023
Nicoleta Mădălina NIȚĂ, Aurel Mihail Țîțu   +1 more
openalex   +1 more source

A Taxonomy of Software Engineering Challenges for Machine Learning Systems: An Empirical Investigation

International Conference on Agile Software Development, 2019
Artificial intelligence enabled systems have been an inevitable part of everyday life. However, efficient software engineering principles and processes need to be considered and extended when developing AI- enabled systems. The objective of this study is
Lucy Ellen Lwakatare, Aiswarya Raj, J. Bosch, H. H. Olsson, I. Crnkovic   +4 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

National Wildlife Refuges and Intensive Management in Alaska: Another Case for Preemption [PDF]

, 2010
Developing high quality software is difficult. Traditional software engineering methods emphasizes on structured and linear workflow of activities methods that have been criticized due to their rigid and inflexible nature.
Joly, Julie Lurman
core   +1 more source