Results 101 to 110 of about 7,830,371 (321)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Software engineering activities at SEI (Software Engineering Institute) [PDF]

open access: yes
Prototyping was shown to ease system specification and implementation, especially in the area of user interfaces. Other prototyping approaches do not allow for the evolution of the prototype into a production system or support maintenance after the ...
Chittister, Clyde
core   +1 more source

Big Data Software Engineering: Analysis of Knowledge Domains and Skill Sets Using LDA-Based Topic Modeling

open access: yesIEEE Access, 2019
Software engineering is a data-driven discipline and an integral part of data science. The introduction of big data systems has led to a great transformation in the architecture, methodologies, knowledge domains, and skills related to software ...
Fatih Gurcan, N. Cagiltay
semanticscholar   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

A Process Algebra Software Engineering Environment

open access: yes, 2008
In previous work we described how the process algebra based language PSF can be used in software engineering, using the ToolBus, a coordination architecture also based on process algebra, as implementation model.
Diertens, B.
core  

App Store Effects on Software Engineering Practices

open access: yesIEEE Transactions on Software Engineering, 2019
In this paper, we study the app store as a phenomenon from the developers’ perspective to investigate the extent to which app stores affect software engineering tasks.
A. Al-Subaihin   +4 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Teaching Software Development to Non-Software Engineering Students [PDF]

open access: yes
This paper argues that although the object-oriented programming (OOP) paradigm is appropriate for students taking programming modules on Higher Education (HE) software engineering course, this paradigm is not as relevant for students from other courses ...
Colvin, John
core  

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