Results 131 to 140 of about 3,239,365 (319)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Better research software tools to elevate the rate of scientific discovery or why we need to invest in research software engineering. [PDF]
Front Bioinform, 2023 Deschamps J, Dalle Nogare D, Jug F.
europepmc +1 more source
Integrating Risk Into An Engineering Economy Course With Simulation Software [PDF]
, 2020 Rita L. Endt, Eyler Robert Coates
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Software selection in large-scale software engineering: A model and criteria based on interactive rapid reviews. [PDF]
Empir Softw Eng, 2023 Bjarnason E, Åberg P, Ali NB.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Infrastructural justice for responsible software engineering,
Journal of Responsible TechnologyIn recent years, we have seen many examples of software products unintentionally causing demonstrable harm. Many guidelines for ethical and responsible computing have been developed in response. Dominant approaches typically attribute liability and blame
Sarah Robinson +8 more
doaj +1 more source
Towards improving decision making and estimating the value of decisions in value-based software engineering: the VALUE framework [PDF]
, 2017 Emília Mendes +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source