Results 151 to 160 of about 1,132,150 (310)

Software Engineering for Real-Time: A Roadmap

open access: yes, 2000
The next ten years will see distributed real-time computer systems replacing many mechanical and hydraulic control systems in high-dependability applications.
Software Engineering, Hermann Kopetz
core  

Reflections on Software Engineering Education

open access: yes, 2006
In recent years, the software engineering community has focused on organizing its existing knowledge and finding opportunities to transform that knowledge into a university curriculum.
van Vliet, H.
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Infrastructural justice for responsible software engineering,

open access: yesJournal of Responsible Technology
In recent years, we have seen many examples of software products unintentionally causing demonstrable harm. Many guidelines for ethical and responsible computing have been developed in response. Dominant approaches typically attribute liability and blame
Sarah Robinson   +8 more
doaj   +1 more source

Curriculum Issues in Industry Oriented Software Engineering Education

open access: yes, 2012
Mishra, Deepti/0000-0001-5144-3811; Mishra, Alok/0000-0003-1275-2050Software engineering education has been emerging as an independent and mature discipline.
Mıshra, Deepti   +3 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Software Practice from the Inside: Ethnography Applied to Software Engineering

open access: yes, 2002
Empirical methodologies have recently attracted increasing attention from the broader software engineering community. In particular, organisational issues and the human role in software development have been addressed.
Rönkkö, Kari
core  

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